Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection

Valentina Svicher; Valeria Cento; Martina Bernassola; Maria Neumann-Fraune; Formijn Van Hemert; Mengjie Chen; Romina Salpini; Chang Liu; Roberta Longo; Michela Visca; Sara Romano; Valeria Micheli; Ada Bertoli; Caterina Gori; Francesca Ceccherini-Silberstein; Cesare Sarrecchia; Massimo Andreoni; Mario Angelico; Antonella Ursitti; Alberto Spanò; Jing Maria Zhang; Jens Verheyen; Giuseppina Cappiello; Carlo Federico Perno

doi:10.1016/j.antiviral.2011.10.022

Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection

Valentina Svicher, Valeria Cento, Martina Bernassola, Maria Neumann-Fraune, Formijn Van Hemert, Mengjie Chen, Romina Salpini, Chang Liu, Roberta Longo, Michela Visca, Sara Romano, Valeria Micheli, Ada Bertoli, Caterina Gori, Francesca Ceccherini-Silberstein, Cesare Sarrecchia, Massimo Andreoni, Mario Angelico, Antonella Ursitti, Alberto SpanòJing Maria Zhang, Jens Verheyen, Giuseppina Cappiello, Carlo Federico Perno

Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani

Research output: Contribution to journal › Article › peer-review

Abstract

Occult HBV infection (OBI) is a threat for the safety of blood-supply, and has been associated with the onset of HBV-related hepatocellular carcinoma and lymphomagenesis. Nevertheless, genetic markers in HBsAg (particularly in D-genotype, the most common in Europe) significantly associated with OBI in vivo are missing. Thus, the goal of this study is to define: (i) prevalence and clinical profile of OBI among blood-donors; (ii) HBsAg-mutations associated with OBI; (iii) their impact on HBsAg-detection. OBI was searched among 422,278 blood-donors screened by Nucleic-Acid-Testing. Following Taormina-OBI-definition, 26 (0.006%) OBI-patients were identified. Despite viremia

Original language	English
Pages (from-to)	86-93
Number of pages	8
Journal	Antiviral Research
Volume	93
Issue number	1
DOIs	https://doi.org/10.1016/j.antiviral.2011.10.022
Publication status	Published - Jan 2012

Keywords

HBsAg detection
HBsAg structure
HBV
Occult infection

ASJC Scopus subject areas

Virology
Pharmacology

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10.1016/j.antiviral.2011.10.022

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Svicher, V., Cento, V., Bernassola, M., Neumann-Fraune, M., Hemert, F. V., Chen, M., Salpini, R., Liu, C., Longo, R., Visca, M., Romano, S., Micheli, V., Bertoli, A., Gori, C., Ceccherini-Silberstein, F., Sarrecchia, C., Andreoni, M., Angelico, M., Ursitti, A., ... Perno, C. F. (2012). Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection. Antiviral Research, 93(1), 86-93. https://doi.org/10.1016/j.antiviral.2011.10.022

Svicher, V, Cento, V, Bernassola, M, Neumann-Fraune, M, Hemert, FV, Chen, M, Salpini, R, Liu, C, Longo, R, Visca, M, Romano, S, Micheli, V, Bertoli, A, Gori, C, Ceccherini-Silberstein, F, Sarrecchia, C, Andreoni, M, Angelico, M, Ursitti, A, Spanò, A, Zhang, JM, Verheyen, J, Cappiello, G & Perno, CF 2012, 'Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection', Antiviral Research, vol. 93, no. 1, pp. 86-93. https://doi.org/10.1016/j.antiviral.2011.10.022

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abstract = "Occult HBV infection (OBI) is a threat for the safety of blood-supply, and has been associated with the onset of HBV-related hepatocellular carcinoma and lymphomagenesis. Nevertheless, genetic markers in HBsAg (particularly in D-genotype, the most common in Europe) significantly associated with OBI in vivo are missing. Thus, the goal of this study is to define: (i) prevalence and clinical profile of OBI among blood-donors; (ii) HBsAg-mutations associated with OBI; (iii) their impact on HBsAg-detection. OBI was searched among 422,278 blood-donors screened by Nucleic-Acid-Testing. Following Taormina-OBI-definition, 26 (0.006%) OBI-patients were identified. Despite viremia ",

keywords = "HBsAg detection, HBsAg structure, HBV, Occult infection",

author = "Valentina Svicher and Valeria Cento and Martina Bernassola and Maria Neumann-Fraune and Hemert, {Formijn Van} and Mengjie Chen and Romina Salpini and Chang Liu and Roberta Longo and Michela Visca and Sara Romano and Valeria Micheli and Ada Bertoli and Caterina Gori and Francesca Ceccherini-Silberstein and Cesare Sarrecchia and Massimo Andreoni and Mario Angelico and Antonella Ursitti and Alberto Span{\`o} and Zhang, {Jing Maria} and Jens Verheyen and Giuseppina Cappiello and Perno, {Carlo Federico}",

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AU - Svicher, Valentina

AU - Cento, Valeria

AU - Bernassola, Martina

AU - Neumann-Fraune, Maria

AU - Hemert, Formijn Van

AU - Chen, Mengjie

AU - Salpini, Romina

AU - Liu, Chang

AU - Longo, Roberta

AU - Visca, Michela

AU - Romano, Sara

AU - Micheli, Valeria

AU - Bertoli, Ada

AU - Gori, Caterina

AU - Ceccherini-Silberstein, Francesca

AU - Sarrecchia, Cesare

AU - Andreoni, Massimo

AU - Angelico, Mario

AU - Ursitti, Antonella

AU - Spanò, Alberto

AU - Zhang, Jing Maria

AU - Verheyen, Jens

AU - Cappiello, Giuseppina

AU - Perno, Carlo Federico

PY - 2012/1

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KW - HBsAg detection

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Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection

Abstract

Keywords

ASJC Scopus subject areas

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