Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection

Valentina Svicher, Valeria Cento, Martina Bernassola, Maria Neumann-Fraune, Formijn Van Hemert, Mengjie Chen, Romina Salpini, Chang Liu, Roberta Longo, Michela Visca, Sara Romano, Valeria Micheli, Ada Bertoli, Caterina Gori, Francesca Ceccherini-Silberstein, Cesare Sarrecchia, Massimo Andreoni, Mario Angelico, Antonella Ursitti, Alberto SpanòJing Maria Zhang, Jens Verheyen, Giuseppina Cappiello, Carlo Federico Perno

Research output: Contribution to journalArticlepeer-review


Occult HBV infection (OBI) is a threat for the safety of blood-supply, and has been associated with the onset of HBV-related hepatocellular carcinoma and lymphomagenesis. Nevertheless, genetic markers in HBsAg (particularly in D-genotype, the most common in Europe) significantly associated with OBI in vivo are missing. Thus, the goal of this study is to define: (i) prevalence and clinical profile of OBI among blood-donors; (ii) HBsAg-mutations associated with OBI; (iii) their impact on HBsAg-detection. OBI was searched among 422,278 blood-donors screened by Nucleic-Acid-Testing. Following Taormina-OBI-definition, 26 (0.006%) OBI-patients were identified. Despite viremia

Original languageEnglish
Pages (from-to)86-93
Number of pages8
JournalAntiviral Research
Issue number1
Publication statusPublished - Jan 2012


  • HBsAg detection
  • HBsAg structure
  • HBV
  • Occult infection

ASJC Scopus subject areas

  • Virology
  • Pharmacology


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