Norepinephrine loss exacerbates methamphetamine-induced striatal dopamine depletion in mice

Francesco Fornai, Lucia Bassi, MariaTilde Torracca, Vera Scalori, Giovanni U. Corsini

Research output: Contribution to journalArticlepeer-review


Evidence is accumulating that norepinephrine depletion enhances the neurotoxic effect of the parkinsonism inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). In this study we investigated whether norepinephrine loss potentiates methamphetamine-induced striatal dopamine depletion. Injection of C57BL/6N mice with methamphetamine (2 × 5 mg/kg i.p., at 2-h intervals) produced only a partial (50%) striatal dopamine depletion 7 days after drug administration. Pretreatment with the selective noradrenergic neurotoxin N-(-2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4; 50 mg/kg i.p.) enhanced methamphetamine-induced striatal dopamine depletion by 86%, without decreasing striatal dopamine levels when injected alone. Our results extend previous findings obtained with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in DSP-4-pretreated mice.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalEuropean Journal of Pharmacology
Issue number1-3
Publication statusPublished - Sept 5 1995


  • DSP-4 (N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine)
  • Locus ceruleus
  • Methamphetamine
  • Striatal dopamine

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience


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