Noninvasive evaluation of left ventricular diastolic function in hypertrophic cardiomyopathy

Carlo Briguori, Sandro Betocchi, Maria Angela Losi, Fiore Manganelli, Federico Piscione, Leonardo Pace, Marco Boccalatte, Rossella Gottilla, Marco Salvatore, Massimo Chiariello

Research output: Contribution to journalArticlepeer-review


Diastolic dysfunction is common in hypertrophic cardiomyopathy (HC). Previous studies suggest that Doppler transmitral flow velocity profiles, and the left atrial (LA) M-mode echogram can be used noninvasively to evaluate left ventricular (LV) diastolic function. However, this has not been proved in HC. In this study we determined the relation of Doppler transmitral flow velocity profiles and the LA M-mode echograms to invasive indexes of LV diastolic function in patients with HC. We studied 25 patients with HC, while off drugs, and calculated LA ~global and active fractional shortening and the slope of both early and late displacement of the posterior aortic wall during LA emptying by M-mode echocardiography. We calculated peak velocity of early (E) and atrial (A) filling, E to A ratio, and E-wave deceleration time by pulsed Doppler echocardiography, and simultaneous radionuclide angiography, LV pressures, time constant of isovolumic relaxation τ, and the constant of chamber stiffness k by cardiac catheterization. The time constant of isovolumic relaxation τ correlated with the slope of early posterior aortic wall displacement (r = 0.59; p <0.01). LV end-diastolic pressure correlated with global LA fractional shortening (r = -0.75; p

Original languageEnglish
Pages (from-to)180-187
Number of pages8
JournalThe American Journal of Cardiology
Issue number2
Publication statusPublished - Jan 15 1998

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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