Non-apoptotic roles for death-related molecules: When mitochondria chose cell fate

Flavie Strappazzon, Silvia Campello, Francesco Cecconi

Research output: Contribution to journalArticlepeer-review


The decision between death and survival is a difficult phase of a cell life. It may depend on the intensity of a stress stimulus, on the presence of invasive pathogens, or on specific signals from neighbouring cells. Death-related molecules are being shown to possess different, and sometimes opposite roles, which they play also according to a number of environmental clues. In this review, we will analyse some of these molecules and their roles, with particular regard to mitochondria-related factors, such as BCL2 family members, the apoptosome components, the autophagy/death cross-talkers and molecules regulating mitochondrial structure and functions. Turning the double-edged swords of death molecules into plougshares may turn out to be strategically crucial in molecular oncology.

Original languageEnglish
Pages (from-to)1309-1315
Number of pages7
JournalExperimental Cell Research
Issue number11
Publication statusPublished - Jul 1 2012


  • Apoptosome
  • Autophagy
  • Caspases
  • Mitochondrial dynamics

ASJC Scopus subject areas

  • Cell Biology


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