Nicotine: Specific role in angiogenesis, proliferation and apoptosis

Alessio Cardinale, Candida Nastrucci, Alfredo Cesario, Patrizia Russo

Research output: Contribution to journalArticlepeer-review


Nowadays, tobacco smoking is the cause of ∼56 million deaths per year, counting 31% and 6% of all cancer deaths (affecting 18 different organs) in middle-aged men and women, respectively. Nicotine is the addictive component of tobacco acting on neuronal nicotinic receptors (nAChR). Functional nAChR, are also present on endothelial, haematological and epithelial cells. Although nicotine itself is regularly not referred to as a carcinogen, there is an ongoing debate whether nicotine functions as a 'tumour promoter'. Nicotine, with its specific binding to nAChR, deregulates essential biological processes like regulation of cell proliferation, apoptosis, migration, invasion, angiogenesis, inflammation and cell-mediated immunity in a wide variety of cells including foetal (regulation of development), embryonic and adult stem cells, adult tissues as well as cancer cells. Nicotine seems involved in fundamental aspects of the biology of malignant diseases, as well as of neurodegeneration. Investigating the biological effects of nicotine may provide new tools for therapeutic interventions and for the understanding of neurodegenerative diseases and tumour biology.

Original languageEnglish
Pages (from-to)68-89
Number of pages22
JournalCritical Reviews in Toxicology
Issue number1
Publication statusPublished - Jan 2012


  • Alzheimer
  • angiogenesis
  • apoptosis
  • cancer
  • cell proliferation
  • NAChR
  • neuronal diseases
  • non-neuronal cells
  • Parkinson
  • Prions

ASJC Scopus subject areas

  • Toxicology


Dive into the research topics of 'Nicotine: Specific role in angiogenesis, proliferation and apoptosis'. Together they form a unique fingerprint.

Cite this