Modificazioni neurovegetative prima e durante episodi di ischemia silente nell'angina variante.

Translated title of the contribution: Neurovegetative changes before and during episodes of silent ischemia in variant angina

E. Bia, G. A. Lanza, A. Manzoli, F. Stazi, G. Colonna, P. Pedrotti, M. Lucente, A. Maseri

Research output: Contribution to journalArticlepeer-review


In order to evaluate whether variations in autonomic nervous tone have a significant role in the induction of coronary arterial spasm in variant angina, we analyzed the changes in heart rate variability (HRV) related to spontaneous episodes of ST-segment elevation, recorded during 24-hour ambulatory ECG monitoring, in 13 patients with variant angina (9 men and 4 women, aged 63 +/- 12 years). In order to obtain an accurate analysis of HRV changes, we only included ischemic episodes characterized by silent ST-segment elevation, lasting at least 3 min and without any ST change in the previous 30 min. HRV indexes in the time domain (RR interval, standard deviation of RR intervals [SD], pNN50, r-MSSD) and in the frequency domain (LF = 0.04-0.15 Hz, HF = 0.15-0.40 HZ, LF/HF ratio) were calculated on 2 min intervals, centered at 15 min before (15B), 5 min before ed 1 min before (1B) the appearance of ST elevation, as well as at peak of ST-segment elevation. Of 161 ischemic episodes found on 24-hour Holter recordings, 60 (37%) fulfilled the inclusion criteria for analysis (4.6 +/- 3.5 episodes/patient, range 1-12). The duration of the selected episodes was 6 +/- 2.5 min and ST elevation was 2.2 +/- 1.0 mm. Heart rate (HR) did not have any change before ST elevation, whereas it showed a small, but significant increase at peak ST (73 +/- 12 versus 67 +/- 11 b/min at 15B, p <0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

Translated title of the contributionNeurovegetative changes before and during episodes of silent ischemia in variant angina
Original languageItalian
Pages (from-to)383-389
Number of pages7
Issue number6
Publication statusPublished - Jun 1994

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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