Neurotensin-induced miosis: The role of dopaminergic pathways

Cristina Tassorelli; Domenico Spampinato; Paolo Caruso; Sebastiano Cavaliere; Giuseppe Micieli; Filippo Drago; Giuseppe Nappi

doi:10.1016/0196-9781(90)90165-2

Neurotensin-induced miosis: The role of dopaminergic pathways

Cristina Tassorelli, Domenico Spampinato, Paolo Caruso, Sebastiano Cavaliere, Giuseppe Micieli, Filippo Drago, Giuseppe Nappi

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 μg to 4 groups of albino rabbits which had previously undergone the following treatment: a) desmethylimipramine IM and, after 30 min, 6-hydroxydopamine IV 7 days prior to the neurotensin administration; b) haloperidol IM for 15 days; c) haloperidol AC 10 minutes before the neurotensin administration. Our data confirm previous observations regarding the miotic activity of neurotensin and suggest that the dopaminergic system plays an important role in the miotic effect of neurotensin.

Original language	English
Pages (from-to)	1309-1311
Number of pages	3
Journal	Peptides
Volume	11
Issue number	6
DOIs	https://doi.org/10.1016/0196-9781(90)90165-2
Publication status	Published - 1990

Keywords

Dopaminergic system
Miosis
Neurotensin

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Cellular and Molecular Neuroscience

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10.1016/0196-9781(90)90165-2

Cite this

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title = "Neurotensin-induced miosis: The role of dopaminergic pathways",

abstract = "In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 μg to 4 groups of albino rabbits which had previously undergone the following treatment: a) desmethylimipramine IM and, after 30 min, 6-hydroxydopamine IV 7 days prior to the neurotensin administration; b) haloperidol IM for 15 days; c) haloperidol AC 10 minutes before the neurotensin administration. Our data confirm previous observations regarding the miotic activity of neurotensin and suggest that the dopaminergic system plays an important role in the miotic effect of neurotensin.",

keywords = "Dopaminergic system, Miosis, Neurotensin",

author = "Cristina Tassorelli and Domenico Spampinato and Paolo Caruso and Sebastiano Cavaliere and Giuseppe Micieli and Filippo Drago and Giuseppe Nappi",

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volume = "11",

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TY - JOUR

T1 - Neurotensin-induced miosis

T2 - The role of dopaminergic pathways

AU - Tassorelli, Cristina

AU - Spampinato, Domenico

AU - Caruso, Paolo

AU - Cavaliere, Sebastiano

AU - Micieli, Giuseppe

AU - Drago, Filippo

AU - Nappi, Giuseppe

PY - 1990

Y1 - 1990

N2 - In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 μg to 4 groups of albino rabbits which had previously undergone the following treatment: a) desmethylimipramine IM and, after 30 min, 6-hydroxydopamine IV 7 days prior to the neurotensin administration; b) haloperidol IM for 15 days; c) haloperidol AC 10 minutes before the neurotensin administration. Our data confirm previous observations regarding the miotic activity of neurotensin and suggest that the dopaminergic system plays an important role in the miotic effect of neurotensin.

AB - In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 μg to 4 groups of albino rabbits which had previously undergone the following treatment: a) desmethylimipramine IM and, after 30 min, 6-hydroxydopamine IV 7 days prior to the neurotensin administration; b) haloperidol IM for 15 days; c) haloperidol AC 10 minutes before the neurotensin administration. Our data confirm previous observations regarding the miotic activity of neurotensin and suggest that the dopaminergic system plays an important role in the miotic effect of neurotensin.

KW - Dopaminergic system

KW - Miosis

KW - Neurotensin

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JO - Peptides

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ER -

Neurotensin-induced miosis: The role of dopaminergic pathways

Abstract

Keywords

ASJC Scopus subject areas

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