Neuroprotection and enhanced recovery with Hypericum perforatum extract after experimental spinal cord injury in mice

Tiziana Genovese, Emanuela Mazzon, Marta Menegazzi, Rosanna Di Paola, Carmelo Muià, Concetta Crisafulli, Placido Bramanti, Hisanori Suzuki, Salvatore Cuzzocrea

Research output: Contribution to journalArticlepeer-review


Oxidative stress results from an oxidant/antioxidant imbalance, an excess of oxidants, and/or a depletion of antioxidants. A considerable body of recent evidence suggests that oxidative stress and exaggerated production of reactive oxygen species play a major role in several aspects of inflammation. Hypericum perforatum is a medicinal plant species containing many polyphenolic compounds, namely, flavonoids and phenolic acids. Because polyphenolic compounds have high antioxidant potential, in this study, we evaluated the effect of H. perforatum (given at 30 mg • kg) in an experimental animal model of spinal cord injury, which was induced by the application of vascular clips to the dura via a four-level T5 through T8 laminectomy. The degree of (a) spinal cord inflammation and tissue injury (histological score), (b) nitrotyrosine, (c) poly(adenosine diphosphate-ribose), (d) neutrophils infiltration, and (e) the activation of signal transducer and activator transcription 3 was markedly reduced in spinal cord tissue obtained from H. perforatum extract-treated mice. We have also demonstrated that H. perforatum extract significantly ameliorated the recovery of limb function.

Original languageEnglish
Pages (from-to)608-617
Number of pages10
Issue number6
Publication statusPublished - Jun 2006


  • Inflammation
  • Neutrophil infiltration
  • Oxidative stress
  • PAR
  • Polyphenols
  • STAT-3

ASJC Scopus subject areas

  • Physiology
  • Critical Care and Intensive Care Medicine


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