Neuroplasticity in adult human visual cortex: Neuroscience and Biobehavioral Reviews

E. Castaldi, C. Lunghi, M.C. Morrone

Research output: Contribution to journalArticlepeer-review


Between 1-5:100 people worldwide have never experienced normotypic vision due to a condition called amblyopia, and about 1:4000 suffer from inherited retinal dystrophies that progressively lead to blindness. While a wide range of technologies and therapies are being developed to restore vision, a fundamental question still remains unanswered: would the adult visual brain retain a sufficient plastic potential to learn how to ‘see’ after a prolonged period of abnormal visual experience? In this review we summarize studies showing that the visual brain of sighted adults retains a type of developmental plasticity, called homeostatic plasticity, and this property has been recently exploited successfully for adult amblyopia recovery. Next, we discuss how the brain circuits reorganize when blindness occurs and when visual stimulation is partially restored by means of a ‘bionic eye’ in late blind adults with Retinitis Pigmentosa. The primary visual cortex in these patients slowly became activated by the artificial visual stimulation, indicating that sight restoration therapies can rely on a considerable degree of spared plasticity in adulthood. © 2020 The Authors
Original languageEnglish
Pages (from-to)542-552
Number of pages11
JournalNeurosci. Biobehav. Rev.
Publication statusPublished - 2020


  • 7T fMRI
  • Amblyopia
  • Binocular rivalry
  • Bionic eye
  • Blindness
  • Cortical excitability
  • Critical period
  • Cross-modal plasticity
  • Retinal prosthesis
  • Retinitis pigmentosa
  • Short-term monocular deprivation
  • Visual restoration
  • adulthood
  • amblyopia
  • blindness
  • brain development
  • brain function
  • functional assessment
  • homeostasis
  • human
  • kinesiotherapy
  • nerve cell plasticity
  • nerve potential
  • neurochemistry
  • neurologic examination
  • nonhuman
  • priority journal
  • retina dystrophy
  • Review
  • visual cortex
  • visual deprivation
  • visual disorder
  • visual nervous system
  • visual stimulation


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