Neuropathy and anti-MAG antibodies without detectable serum M-protein

Eduardo Nobile-Orazio, Norman Latov, Arthur P. Hays, Masami Takatsu, Gary M. Abrams, William H. Sherman, James R. Miller, Mary Jo Messito, Toyokazu Saito, Albert Tahmoush, Robert E. Lovelace, Lewis P. Rowland

Research output: Contribution to journalArticlepeer-review


Anti-MAG IgM antibodies were detected by ELISA in a patient with slowly progressive peripheral neuropathy. Serum IgM content was normal, and no M-protein was detected by serum protein elec-trophoresis, immunoelectrophoresis, or immunostaining. By immunoblot analysis, the anti-MAG antibodies were IgMk; they reacted with human and bovine MAG but not with mouse MAG. The data suggest that there was an anti-MAG IgM M-protein in concentration too low to be detected by conventional techniques. Tests for anti-MAG antibodies should be done in patients with slowly progressive neuropathy of unknown etiology, even in the absence of detectable serum M-protein.

Original languageEnglish
Pages (from-to)218-221
Number of pages4
Issue number2
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)


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