Neuropathy and anti-MAG antibodies without detectable serum M-protein

Eduardo Nobile-Orazio; Norman Latov; Arthur P. Hays; Masami Takatsu; Gary M. Abrams; William H. Sherman; James R. Miller; Mary Jo Messito; Toyokazu Saito; Albert Tahmoush; Robert E. Lovelace; Lewis P. Rowland

Neuropathy and anti-MAG antibodies without detectable serum M-protein

Eduardo Nobile-Orazio, Norman Latov, Arthur P. Hays, Masami Takatsu, Gary M. Abrams, William H. Sherman, James R. Miller, Mary Jo Messito, Toyokazu Saito, Albert Tahmoush, Robert E. Lovelace, Lewis P. Rowland

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Anti-MAG IgM antibodies were detected by ELISA in a patient with slowly progressive peripheral neuropathy. Serum IgM content was normal, and no M-protein was detected by serum protein elec-trophoresis, immunoelectrophoresis, or immunostaining. By immunoblot analysis, the anti-MAG antibodies were IgM_k; they reacted with human and bovine MAG but not with mouse MAG. The data suggest that there was an anti-MAG IgM M-protein in concentration too low to be detected by conventional techniques. Tests for anti-MAG antibodies should be done in patients with slowly progressive neuropathy of unknown etiology, even in the absence of detectable serum M-protein.

Original language	English
Pages (from-to)	218-221
Number of pages	4
Journal	Neurology
Volume	34
Issue number	2
Publication status	Published - 1984

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology
Neuroscience(all)

Cite this

@article{f531300aeca24606b5bede2e545e45c4,

title = "Neuropathy and anti-MAG antibodies without detectable serum M-protein",

abstract = "Anti-MAG IgM antibodies were detected by ELISA in a patient with slowly progressive peripheral neuropathy. Serum IgM content was normal, and no M-protein was detected by serum protein elec-trophoresis, immunoelectrophoresis, or immunostaining. By immunoblot analysis, the anti-MAG antibodies were IgMk; they reacted with human and bovine MAG but not with mouse MAG. The data suggest that there was an anti-MAG IgM M-protein in concentration too low to be detected by conventional techniques. Tests for anti-MAG antibodies should be done in patients with slowly progressive neuropathy of unknown etiology, even in the absence of detectable serum M-protein.",

author = "Eduardo Nobile-Orazio and Norman Latov and Hays, {Arthur P.} and Masami Takatsu and Abrams, {Gary M.} and Sherman, {William H.} and Miller, {James R.} and Messito, {Mary Jo} and Toyokazu Saito and Albert Tahmoush and Lovelace, {Robert E.} and Rowland, {Lewis P.}",

year = "1984",

language = "English",

volume = "34",

pages = "218--221",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Neuropathy and anti-MAG antibodies without detectable serum M-protein

AU - Nobile-Orazio, Eduardo

AU - Latov, Norman

AU - Hays, Arthur P.

AU - Takatsu, Masami

AU - Abrams, Gary M.

AU - Sherman, William H.

AU - Miller, James R.

AU - Messito, Mary Jo

AU - Saito, Toyokazu

AU - Tahmoush, Albert

AU - Lovelace, Robert E.

AU - Rowland, Lewis P.

PY - 1984

Y1 - 1984

N2 - Anti-MAG IgM antibodies were detected by ELISA in a patient with slowly progressive peripheral neuropathy. Serum IgM content was normal, and no M-protein was detected by serum protein elec-trophoresis, immunoelectrophoresis, or immunostaining. By immunoblot analysis, the anti-MAG antibodies were IgMk; they reacted with human and bovine MAG but not with mouse MAG. The data suggest that there was an anti-MAG IgM M-protein in concentration too low to be detected by conventional techniques. Tests for anti-MAG antibodies should be done in patients with slowly progressive neuropathy of unknown etiology, even in the absence of detectable serum M-protein.

AB - Anti-MAG IgM antibodies were detected by ELISA in a patient with slowly progressive peripheral neuropathy. Serum IgM content was normal, and no M-protein was detected by serum protein elec-trophoresis, immunoelectrophoresis, or immunostaining. By immunoblot analysis, the anti-MAG antibodies were IgMk; they reacted with human and bovine MAG but not with mouse MAG. The data suggest that there was an anti-MAG IgM M-protein in concentration too low to be detected by conventional techniques. Tests for anti-MAG antibodies should be done in patients with slowly progressive neuropathy of unknown etiology, even in the absence of detectable serum M-protein.

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C2 - 6198602

AN - SCOPUS:0021348677

SN - 0028-3878

VL - 34

SP - 218

EP - 221

JO - Neurology

JF - Neurology

IS - 2

ER -

Neuropathy and anti-MAG antibodies without detectable serum M-protein

Abstract

ASJC Scopus subject areas

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