Neurochemical and behavioural modifications induced by scrapie infection in golden hamsters

S. R. Bareggi; D. Braida; M. Gervasoni; G. Carcassola; C. Pollera; C. Vergerio; M. Sala

doi:10.1016/S0006-8993(03)03154-8

Neurochemical and behavioural modifications induced by scrapie infection in golden hamsters

S. R. Bareggi, D. Braida, M. Gervasoni, G. Carcassola, C. Pollera, C. Vergerio, M. Sala

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

Scrapie-infected hamsters were tested for spontaneous motor activity and passive avoidance at various times after infection. After testing, some animals were killed and their whole brains assayed for norepinephrine, dopamine, serotonin and their metabolites. The apparent rate of turnover was estimated in terms of metabolite/amine concentrations. After 70 days, there was a decrease in passive avoidance and dopamine and serotonin. Passive avoidance correlated with the apparent rate of turnover of dopamine, whereas motor activity correlated with that of serotonin and dopamine.

Original language	English
Pages (from-to)	237-241
Number of pages	5
Journal	Brain Research
Volume	984
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(03)03154-8
Publication status	Published - Sept 12 2003

Keywords

Brain monoamine
Motor activity
Neurodegenerative prion disease
Passive avoidance

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0006-8993(03)03154-8

Cite this

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abstract = "Scrapie-infected hamsters were tested for spontaneous motor activity and passive avoidance at various times after infection. After testing, some animals were killed and their whole brains assayed for norepinephrine, dopamine, serotonin and their metabolites. The apparent rate of turnover was estimated in terms of metabolite/amine concentrations. After 70 days, there was a decrease in passive avoidance and dopamine and serotonin. Passive avoidance correlated with the apparent rate of turnover of dopamine, whereas motor activity correlated with that of serotonin and dopamine.",

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AU - Bareggi, S. R.

AU - Braida, D.

AU - Gervasoni, M.

AU - Carcassola, G.

AU - Pollera, C.

AU - Vergerio, C.

AU - Sala, M.

PY - 2003/9/12

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AB - Scrapie-infected hamsters were tested for spontaneous motor activity and passive avoidance at various times after infection. After testing, some animals were killed and their whole brains assayed for norepinephrine, dopamine, serotonin and their metabolites. The apparent rate of turnover was estimated in terms of metabolite/amine concentrations. After 70 days, there was a decrease in passive avoidance and dopamine and serotonin. Passive avoidance correlated with the apparent rate of turnover of dopamine, whereas motor activity correlated with that of serotonin and dopamine.

KW - Brain monoamine

KW - Motor activity

KW - Neurodegenerative prion disease

KW - Passive avoidance

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Neurochemical and behavioural modifications induced by scrapie infection in golden hamsters

Abstract

Keywords

ASJC Scopus subject areas

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