Neuraxial block and postoperative epidural analgesia: Effects on outcomes in the POISE-2 trial

K. Leslie, D. McIlroy, J. Kasza, A. Forbes, A. Kurz, J. Khan, C. S. Meyhoff, R. Allard, G. Landoni, X. Jara, G. Lurati Buse, K. Candiotti, H. S. Lee, R. Gupta, T. Vanhelder, W. Purayil, S. De Hert, T. Treschan, P. J. Devereaux, H. C. Hemmings

Research output: Contribution to journalArticlepeer-review


Background. We assessed associations between intraoperative neuraxial block and postoperative epidural analgesia, and a composite primary outcome of death or non-fatal myocardial infarction, at 30 days post-randomization in POISE-2 Trial subjects. Methods. 10 010 high-risk noncardiac surgical patients were randomized aspirin or placebo and clonidine or placebo. Neuraxial block was defined as intraoperative spinal anaesthesia, or thoracic or lumbar epidural anaesthesia. Postoperative epidural analgesia was defined as postoperative epidural local anaesthetic and/or opioid administration. We used logistic regression with weighting using estimated propensity scores. Results. Neuraxial block was not associated with the primary outcome [7.5% vs 6.5%; odds ratio (OR), 0.89; 95% CI (confidence interval), 0.73-1.08; P=0.24], death (1.0% vs 1.4%; OR, 0.84; 95% CI, 0.53-1.35; P=0.48), myocardial infarction (6.9% vs 5.5%; OR, 0.91; 95% CI, 0.74-1.12; P=0.36) or stroke (0.3% vs 0.4%; OR, 1.05; 95% CI, 0.44-2.49; P=0.91). Neuraxial block was associated with less clinically important hypotension (39% vs 46%; OR, 0.90; 95% CI, 0.81-1.00; P=0.04). Postoperative epidural analgesia was not associated with the primary outcome (11.8% vs 6.2%; OR, 1.48; 95% CI, 0.89-2.48; P=0.13), death (1.3% vs 0.8%; OR, 0.84; 95% CI, 0.35-1.99; P=0.68], myocardial infarction (11.0% vs 5.7%; OR, 1.53; 95% CI, 0.90-2.61; P=0.11], stroke (0.4% vs 0.4%; OR, 0.65; 95% CI, 0.18-2.32; P=0.50] or clinically important hypotension (63% vs 36%; OR, 1.40; 95% CI, 0.95-2.09; P=0.09). Conclusions. Neuraxial block and postoperative epidural analgesia were not associated with adverse cardiovascular outcomes among POISE-2 subjects.

Original languageEnglish
Pages (from-to)100-112
Number of pages13
JournalBritish Journal of Anaesthesia
Issue number1
Publication statusPublished - Jan 1 2016


  • anaesthesia
  • death
  • epidural
  • myocardial infarction
  • spinal
  • stroke

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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