Neural control of the kidney - are there reno-renal reflexes?

A. Zanchetti, A. Stella, R. Golin, S. Genovesi

Research output: Contribution to journalArticlepeer-review


Circulatory, secretory (renin release) and excretory (tubular sodium and water reabsorpticn) renal functions are known to be under neural control exerted by sympathetic fibers. Influences on circulatory and secretory functions are modulated by vagally mediated reflexes originated from low pressure (or volume) receptors in the cardiopulmonary area. The possibility that renorenal reflexes may also exist has raised interest recently. Mechanoreceptors and chemoreceptors have been described in the kidney, and electrophysiological evidence of renorenal reflexes is available. However, electrical stimulation of afferent renal nerves has failed to reflexly influence circulatory, secretory and excretory functions of the contralateral kidney. Deafferentation studies have been more successful, however. Transient denervation of one kidney by renal nerve cooling is accompanied by reduction of sodium and water excretion from the contralateral kidney with negligible changes in blood flow and glomerular filtration rate. The contralateral antidiuretic activity is prevented either by denervation of the contralateral kidney or by interruption of the afferent fibers running in the spinal dorsal roots. This definite ly shows that a reno-renal reflex exists, consisting in-a tonic inhibition of contralateral Sympathetic activity controllinq tubular reabsorption of sodium and water, and renin release.

Original languageEnglish
Pages (from-to)275-286
Number of pages12
JournalClinical and Experimental Hypertension
Issue number1-2
Publication statusPublished - 1984


  • Afferent Renal Nerves
  • Neural Control
  • Reno-renal Reflex
  • Tubular Function

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology


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