Negative results of short-term genotoxicity tests with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene

Tommaso A. Dragani; Roberto Barale; Silvio Parodi; Maurizio Taningher; Donatella Zucconi; Giuseppe Della Porta

Negative results of short-term genotoxicity tests with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene

Tommaso A. Dragani, Roberto Barale, Silvio Parodi, Maurizio Taningher, Donatella Zucconi, Giuseppe Della Porta

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

The phenobarbital-like enzyme inducer and tumor promoter of murine hepatocarcinogenesis, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene has been assayed in short-term genotoxicity tests, i.e. the Salmonella mutagenicity test, micronucleus and chromosomal aberrations analysis in mouse bone marrow cells in vivo, DNA alkaline elution and DNA unwinding assays in mouse liver in vivo. All the assays performed proved negative.

Original language	English
Pages (from-to)	1153-1157
Number of pages	5
Journal	Carcinogenesis
Volume	11
Issue number	7
Publication status	Published - Jul 1990

ASJC Scopus subject areas

Cancer Research
Statistics, Probability and Uncertainty
Applied Mathematics
Physiology (medical)
Physiology
Behavioral Neuroscience

Cite this

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abstract = "The phenobarbital-like enzyme inducer and tumor promoter of murine hepatocarcinogenesis, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene has been assayed in short-term genotoxicity tests, i.e. the Salmonella mutagenicity test, micronucleus and chromosomal aberrations analysis in mouse bone marrow cells in vivo, DNA alkaline elution and DNA unwinding assays in mouse liver in vivo. All the assays performed proved negative.",

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AU - Taningher, Maurizio

AU - Zucconi, Donatella

AU - Della Porta, Giuseppe

PY - 1990/7

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AB - The phenobarbital-like enzyme inducer and tumor promoter of murine hepatocarcinogenesis, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene has been assayed in short-term genotoxicity tests, i.e. the Salmonella mutagenicity test, micronucleus and chromosomal aberrations analysis in mouse bone marrow cells in vivo, DNA alkaline elution and DNA unwinding assays in mouse liver in vivo. All the assays performed proved negative.

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Negative results of short-term genotoxicity tests with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene

Abstract

ASJC Scopus subject areas

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