Negative results of short-term genotoxicity tests with 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene

Tommaso A. Dragani, Roberto Barale, Silvio Parodi, Maurizio Taningher, Donatella Zucconi, Giuseppe Della Porta

Research output: Contribution to journalArticlepeer-review


The phenobarbital-like enzyme inducer and tumor promoter of murine hepatocarcinogenesis, 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene has been assayed in short-term genotoxicity tests, i.e. the Salmonella mutagenicity test, micronucleus and chromosomal aberrations analysis in mouse bone marrow cells in vivo, DNA alkaline elution and DNA unwinding assays in mouse liver in vivo. All the assays performed proved negative.

Original languageEnglish
Pages (from-to)1153-1157
Number of pages5
Issue number7
Publication statusPublished - Jul 1990

ASJC Scopus subject areas

  • Cancer Research
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Physiology
  • Behavioral Neuroscience


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