Nasal irrigation with saline solution significantly improves oxygen saturation in infants with bronchiolitis

Silvana Schreiber, Luca Ronfani, Sergio Ghirardo, Federico Minen, Andrea Taddio, Mohamad Jaber, Elisa Rizzello, Egidio Barbi

Research output: Contribution to journalArticlepeer-review


Aim Published guidelines do not recommend nasal irrigation in bronchiolitis, but it is common practice in Italy, despite a lack of data on its benefits or adverse effects. This single-blind, multicentre, randomised controlled trial compared nasal irrigation using either isotonic 0.9% sodium chloride or hypertonic 3% sodium chloride with simple supportive care in infants with bronchiolitis. Methods We randomly assigned 133 infants up one year of age, who were admitted to the emergency department with bronchiolitis and an oxygen saturation (SpO2) of between 88 and 94%, to the isotonic (n = 47), hypertonic (n = 44) or standard care (n = 42) groups. Variations in SpO2 and the wheeze, air exchange, respiratory rate, muscle use (WARM) respiratory distress score were recorded at zero, five, 15, 20 and 50 minutes. Results Five minutes after the intervention, the median SpO2 value (95%) in the isotonic group was higher than both the hypertonic (94%) and the standard care (93%) groups. The differences between the isotonic and standard treatment groups were statistically significant at each time point, while the hypertonic group only reached significantly higher values after 50 minutes. However, the WARM score did not improve. Conclusion A single nasal irrigation with saline solution significantly improved oxygen saturation in infants with bronchiolitis.

Original languageEnglish
Pages (from-to)292-296
Number of pages5
JournalActa Paediatrica, International Journal of Paediatrics
Issue number3
Publication statusPublished - Mar 1 2016


  • Bronchiolitis
  • Nasal irrigation
  • Oxygen saturation
  • Respiratory distress
  • Sodium chloride

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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