TY - JOUR
T1 - Myasthenia gravis outcome measure
T2 - Development and validation of a disease-specific self-administered questionnaire
AU - Padua, L.
AU - Evoli, A.
AU - Aprile, I.
AU - Caliandro, P.
AU - Batocchi, A. P.
AU - Punzi, C.
AU - Mazza, S.
AU - Padua, R.
AU - Tonali, P.
PY - 2002/6
Y1 - 2002/6
N2 - We describe the development and validation of an outcome measure for patients with myasthenia gravis (MG) and show the correlation of the items with conventional MG measurements. In stage 1, item generation, a group of methodologists, clinical experts generated a list of 56 items. The list was based on (1) a previous study on an MG sample, (2) clinical experience and (3) items proposed by MG patients. In stage 2, reduction of items, the list was reduced on the basis of results from field testing (41 patients completed the 56-item questionnaire). In stage 3, reliability and validity were assessed. A 25-item MG questionnaire (MGQ) was generated. Results were related to conventional measures of MG severity. Furthermore, the MGQ appeared reliable, sensitive and reproducible. The questionnaire was validated as an outcome measure.
AB - We describe the development and validation of an outcome measure for patients with myasthenia gravis (MG) and show the correlation of the items with conventional MG measurements. In stage 1, item generation, a group of methodologists, clinical experts generated a list of 56 items. The list was based on (1) a previous study on an MG sample, (2) clinical experience and (3) items proposed by MG patients. In stage 2, reduction of items, the list was reduced on the basis of results from field testing (41 patients completed the 56-item questionnaire). In stage 3, reliability and validity were assessed. A 25-item MG questionnaire (MGQ) was generated. Results were related to conventional measures of MG severity. Furthermore, the MGQ appeared reliable, sensitive and reproducible. The questionnaire was validated as an outcome measure.
KW - Disease-specific questionnaire
KW - Myasthenia gravis
KW - Patient-oriented
KW - Quality of life
KW - Self-administered questionnaire
KW - SF-36
KW - Validation
UR - http://www.scopus.com/inward/record.url?scp=0036619006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036619006&partnerID=8YFLogxK
U2 - 10.1007/s100720200027
DO - 10.1007/s100720200027
M3 - Article
C2 - 12235493
AN - SCOPUS:0036619006
SN - 1590-1874
VL - 23
SP - 59
EP - 68
JO - Neurological Sciences
JF - Neurological Sciences
IS - 2
ER -