Mutagenic Activity of Transition-Metal Complexes: Relation Structure-Mutagenic and Antibacterial Activity for some Pd(II), Pt(II) and Rh(I) Complexes

Michele Aresta; Sonia Treglia; Mauro Collucia; Mario Correale; Domenico Giordano; Silvana Moscelli

doi:10.1080/02772248409357043

Mutagenic Activity of Transition-Metal Complexes: Relation Structure-Mutagenic and Antibacterial Activity for some Pd(II), Pt(II) and Rh(I) Complexes

Michele Aresta, Sonia Treglia, Mauro Collucia, Mario Correale, Domenico Giordano, Silvana Moscelli

Ente Ospedaliero Specializzato in Gastroenterologia "Saverio de Bellis"

Research output: Contribution to journal › Article › peer-review

Abstract

The inhibitory and mutagenic action of some Pd(II), Pt(II) and Rh(I) complexes towards various bacterial strains has been evaluated, and some correlations have been found between the chemical behaviour of the complexes and their selective biological activity: most of the complexes cause only a DNA damage repaired by the excision repair system. Particularly, the Rh(I) complexes used in this work show selective antibacterial effects on defective but no effect on wild-type strains.

Original language	English
Pages (from-to)	81-94
Number of pages	14
Journal	Toxicological and Environmental Chemistry
Volume	8
Issue number	2-3
DOIs	https://doi.org/10.1080/02772248409357043
Publication status	Published - Jun 1 1984

Keywords

bacteria
DNA damage
mutagenicity
palladium complexes
Platinum complexes
repair systems
rhodium complexes

ASJC Scopus subject areas

Environmental Chemistry
Health, Toxicology and Mutagenesis
Pollution
Environmental Science(all)
Toxicology

Access to Document

10.1080/02772248409357043

Cite this

@article{77966600bcfd4c2298751ffb356875c2,

title = "Mutagenic Activity of Transition-Metal Complexes: Relation Structure-Mutagenic and Antibacterial Activity for some Pd(II), Pt(II) and Rh(I) Complexes",

abstract = "The inhibitory and mutagenic action of some Pd(II), Pt(II) and Rh(I) complexes towards various bacterial strains has been evaluated, and some correlations have been found between the chemical behaviour of the complexes and their selective biological activity: most of the complexes cause only a DNA damage repaired by the excision repair system. Particularly, the Rh(I) complexes used in this work show selective antibacterial effects on defective but no effect on wild-type strains.",

keywords = "bacteria, DNA damage, mutagenicity, palladium complexes, Platinum complexes, repair systems, rhodium complexes",

author = "Michele Aresta and Sonia Treglia and Mauro Collucia and Mario Correale and Domenico Giordano and Silvana Moscelli",

year = "1984",

month = jun,

day = "1",

doi = "10.1080/02772248409357043",

language = "English",

volume = "8",

pages = "81--94",

journal = "Toxicological and Environmental Chemistry",

issn = "0277-2248",

publisher = "Taylor and Francis Ltd.",

number = "2-3",

}

TY - JOUR

T1 - Mutagenic Activity of Transition-Metal Complexes

T2 - Relation Structure-Mutagenic and Antibacterial Activity for some Pd(II), Pt(II) and Rh(I) Complexes

AU - Aresta, Michele

AU - Treglia, Sonia

AU - Collucia, Mauro

AU - Correale, Mario

AU - Giordano, Domenico

AU - Moscelli, Silvana

PY - 1984/6/1

Y1 - 1984/6/1

N2 - The inhibitory and mutagenic action of some Pd(II), Pt(II) and Rh(I) complexes towards various bacterial strains has been evaluated, and some correlations have been found between the chemical behaviour of the complexes and their selective biological activity: most of the complexes cause only a DNA damage repaired by the excision repair system. Particularly, the Rh(I) complexes used in this work show selective antibacterial effects on defective but no effect on wild-type strains.

AB - The inhibitory and mutagenic action of some Pd(II), Pt(II) and Rh(I) complexes towards various bacterial strains has been evaluated, and some correlations have been found between the chemical behaviour of the complexes and their selective biological activity: most of the complexes cause only a DNA damage repaired by the excision repair system. Particularly, the Rh(I) complexes used in this work show selective antibacterial effects on defective but no effect on wild-type strains.

KW - bacteria

KW - DNA damage

KW - mutagenicity

KW - palladium complexes

KW - Platinum complexes

KW - repair systems

KW - rhodium complexes

UR - http://www.scopus.com/inward/record.url?scp=0021612069&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021612069&partnerID=8YFLogxK

U2 - 10.1080/02772248409357043

DO - 10.1080/02772248409357043

M3 - Article

AN - SCOPUS:0021612069

SN - 0277-2248

VL - 8

SP - 81

EP - 94

JO - Toxicological and Environmental Chemistry

JF - Toxicological and Environmental Chemistry

IS - 2-3

ER -

Mutagenic Activity of Transition-Metal Complexes: Relation Structure-Mutagenic and Antibacterial Activity for some Pd(II), Pt(II) and Rh(I) Complexes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this