Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo

Romain Zufferey, Dea Nagy, Ron J. Mandel, Luigi Naldini, Didier Trono

Research output: Contribution to journalArticlepeer-review


Retroviral vectors derived from lentiviruses such as HIV-1 are promising tools for human gene therapy because they mediate the in vive delivery and long-term expression of transgenes in nondividing tissues. We describe an HIV vector system in which the virulence genes env, vif, vpr, vpu, and nef have been deleted. This multiply attenuated vector conserved the ability to transduce growth-arrested cells and monocyte-derived macrophages in culture, and could efficiently deliver genes in vive into adult neurons. These data demonstrate the potential of lentiviral vectors in human gene therapy.

Original languageEnglish
Pages (from-to)871-875
Number of pages5
JournalNature Biotechnology
Issue number9
Publication statusPublished - Sept 1997


  • Gene therapy
  • HIV
  • Retrovital vectors

ASJC Scopus subject areas

  • Microbiology


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