TY - JOUR
T1 - Multiple levels of chemokine receptor regulation in the control of mouse natural killer cell development
AU - Bernardini, Giovanni
AU - Benigni, Giorgia
AU - Antonangeli, Fabrizio
AU - Ponzetta, Andrea
AU - Santoni, Angela
PY - 2014
Y1 - 2014
N2 - Chemokines play a fundamental role in lymphocyte development, mainly attributable to the control of the correct localization in the proper microenvironments of cells undergoing maturation. Natural killer (NK) cell development occurs in the bone marrow (BM) where their localization is regulated by the balance of chemokine function in cell retention into tissues and mobilization into circulation. In addition, NK cells from several extra-medullary tissues are phenotypically and functionally different from their circulating counterpart suggesting that maturation can be completed in organs other than BM. Indeed, a role of chemokines in NK cell localization into tissues during homeostatic conditions is also documented. In this review, we summarize the current notion related to the relevance of several chemokine/chemokine receptor axes in NK cell development with a focus on the regulation of their expression and function.
AB - Chemokines play a fundamental role in lymphocyte development, mainly attributable to the control of the correct localization in the proper microenvironments of cells undergoing maturation. Natural killer (NK) cell development occurs in the bone marrow (BM) where their localization is regulated by the balance of chemokine function in cell retention into tissues and mobilization into circulation. In addition, NK cells from several extra-medullary tissues are phenotypically and functionally different from their circulating counterpart suggesting that maturation can be completed in organs other than BM. Indeed, a role of chemokines in NK cell localization into tissues during homeostatic conditions is also documented. In this review, we summarize the current notion related to the relevance of several chemokine/chemokine receptor axes in NK cell development with a focus on the regulation of their expression and function.
KW - Bone marrow
KW - Chemokine receptor
KW - Lymphocyte development and function
KW - MicroRNA
KW - NK cell
KW - Transcription factors
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U2 - 10.3389/fimmu.2014.00044
DO - 10.3389/fimmu.2014.00044
M3 - Article
AN - SCOPUS:84895524609
SN - 1664-3224
VL - 5
JO - Frontiers in Immunology
JF - Frontiers in Immunology
IS - FEB
M1 - Article 44
ER -