Multiparametric MRI for prostate cancer detection: Performance in patients with prostate-specific antigen values between 2.5 and 10 ng/mL

Antonella Petrillo, Roberta Fusco, Sergio V. Setola, Francesco M. Ronza, Vincenza Granata, Mario Petrillo, Guglielmo Carone, Mario Sansone, Renato Franco, Franco Fulciniti, Sisto Perdonà

Research output: Contribution to journalArticlepeer-review


Purpose To assess the diagnostic performance of multiparametric MRI (mpMRI), in the detection of prostate cancer, including morphologic sequences (mMRI), diffusion-weighted imaging (DWI), and MR spectroscopy (MRS). Combined morphological and functional MRI scoring systems was used for urological-radiological work-up of patients with a prostate-specific antigen (PSA) value ≤ 10 ng/mL. Materials and Methods The study included 136 of 200 consecutive patients with PSA values between 2.5 and 4 ng/mL and an abnormal digital rectal examination (DRE), or patients with PSA values between 4 and 10 ng/mL, independently from DRE. Each patient provided informed consent to undergo at serum free/total PSA ratio (f/t PSA) assay, mMRI, MRS, DWI, and transrectal ultrasonography (TRUS) biopsy. The MRI datasets were scored singularly; then mMRI and DWI, mMRI and MRS data were combined in a coupled score, and finally mMRI, DWI, and MRS data were combined in a single score (cMRI score). Results Scores were correlated to negative biopsies and significant/insignificant Gleason score biopsies. Receiver-operator-characteristic curve and McNemar tests were performed. Cancer was diagnosed in 18% of patients. The cMRI score showed: (i) the highest sensitivity (0.84) and negative predictive value (0.93); (ii) a significant correlation with Gleason score; and (iii) a statistically different median value between significant and insignificant Gleason score. Conclusion The cMRI score could identify patients with a PSA≤10 ng/mL who will have a negative work-up, for its high negative predictive value, and patients at high risk for significant prostate cancer because of its correlation with the Gleason score. J. Magn. Reson. Imaging 2014;39:1206-1212. © 2013 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)1206-1212
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Issue number5
Publication statusPublished - 2014


  • diffusion-weighted imaging
  • Gleason score
  • MRI
  • prostate cancer
  • spectroscopy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


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