Multinucleate cell angiohistiocytoma

G. Annessi, G. Girolomoni, A. Giannetti

Research output: Contribution to journalArticlepeer-review


We report a case of multinucleate cell angiohistiocytoma occurring in a 50-year-old woman and presenting with a 4-year history of asymptomatic red papules on the face. Histologically, there was a dermal vascular proliferation associated with numerous multinucleate cells. Immunohistochemical studies showed vascular spaces surrounded with mature vascular endothelial cells, and the presence of numerous interstitial factor XIIIa+ cells. Multinucleate cells exhibited intermediate filaments of the vimentin type, but were not stained by endothelial cell or macrophage markers, and were factor XIIIa-. This condition must be addressed in the differential diagnosis of other skin vascular proliferations, such as Kaposi's sarcoma and angiofibromas.

Original languageEnglish
Pages (from-to)340-344
Number of pages5
JournalAmerican Journal of Dermatopathology
Issue number4
Publication statusPublished - 1992


  • Angiofibroma
  • Multinucleate cell angiohistiocytoma
  • Skin
  • Vascular tumor

ASJC Scopus subject areas

  • Dermatology
  • Pathology and Forensic Medicine


Dive into the research topics of 'Multinucleate cell angiohistiocytoma'. Together they form a unique fingerprint.

Cite this