Multicentric, multifocal, and recurrent osteoid osteoma of the hip: First case report

Maria Cristina Cortese, Domenico Albano, Carmelo Messina, Giuseppe Perrucchini, Enrico Gallazzi, Mauro Battista Gallazzi, Primo Andrea Daolio, Luca Maria Sconfienza

Research output: Contribution to journalArticlepeer-review


Background: Osteoid osteoma is a benign bone-forming tumour, which very unfrequently has multifocal or multicentric presentation. We report the first known case of a multicentric, multifocal and recurrent osteoid osteoma treated using radiofrequency ablation. Case presentation: A 39-year-old man with two-year history of left hip pain was admitted at our Institution. The pain was more intense during the night and partially relieved by salicylates. Pelvis CT demonstrated two lytic lesions (8 and 7 mm, respectively) with surrounding sclerotic reactive bone, both with a central focal area of high attenuation, located in the femoral neck and along the anterior portion of the acetabulum, respectively. Both lesions had clinical and imaging findings consistent with multicentric osteoid osteoma. Thus, the two lesions were biopsied - with pathologic confirmation of osteoid osteoma - and treated using radiofrequency ablation. Hip pain decreased but did not disappear, actually increasing a few months after treatment. CT and MRI were performed showing a smaller lesion (5 mm) with the same imaging features, surrounded by marrow oedema, along the posterior column of the acetabulum. The lesion was considered suspicious for osteoid osteoma, overlooked on previous examinations. Therefore, a diagnosis of multicentric and multifocal osteoid osteoma was established. The new lesion was again treated with radiofrequency ablation with symptom disappearance. However, hip pain relapsed after 18 months, and CT and MRI showed an osteoid osteoma recurrence on the posterior column of the acetabulum, which was biopsied and successfully treated using radiofrequency ablation. Conclusions: To our knowledge, this is the first reported case of multicentric, multifocal, recurrent osteoid osteoma. Our case report highlights the importance of considering a diagnosis of multifocal osteoid osteoma when dealing with multifocal lytic lesions of the bone and with pain persistence after treatment. It also emphasises the combined role of CT and MRI in this setting.

Original languageEnglish
Article number171
JournalBMC Musculoskeletal Disorders
Issue number1
Publication statusPublished - Apr 16 2019


  • Computed tomography
  • Hip
  • Magnetic resonance imaging
  • Osteoid osteoma
  • Radiofrequency ablation

ASJC Scopus subject areas

  • Rheumatology
  • Orthopedics and Sports Medicine


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