Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis: The way forward

Wieying Kuo; Mariette P C Kemner Van De Corput; Adria Perez-Rovira; Marleen De Bruijne; Isabelle Fajac; Harm A W M Tiddens; Marcel Van Straten; Laureline Berteloot; Kris De Boeck; Cesare Braggion; Torkel B. Brismar; Rosaria Casciaro; Desmond Cox; Jane C. Davies; C. Kors Van Der Ent; Pilar Garcia Peña; Silvia Gartner; Nanko De Graaf; David Hansell; Lena Hjelte; Herma C. Holscher; Annmarie Jeanes; Pim A. De Jong; Ahmed Kheniche; Timothy Lee; Giorgio Lucigrai; Marco Di Maurizio; Anne Mehl; Anne Munck; Marianne Nuijsink; Jacqueline Payen De La Garanderie; David Rea; Isabelle Sermet; Veronika Skalicka; Florian Streitparth; Philippe Reix; Marleen Smet; Hana Vitouskova

doi:10.1183/13993003.01601-2015

Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis: The way forward

Wieying Kuo, Mariette P C Kemner Van De Corput, Adria Perez-Rovira, Marleen De Bruijne, Isabelle Fajac, Harm A W M Tiddens, Marcel Van Straten, Laureline Berteloot, Kris De Boeck, Cesare Braggion, Torkel B. Brismar, Rosaria Casciaro, Desmond Cox, Jane C. Davies, C. Kors Van Der Ent, Pilar Garcia Peña, Silvia Gartner, Nanko De Graaf, David Hansell, Lena HjelteHerma C. Holscher, Annmarie Jeanes, Pim A. De Jong, Ahmed Kheniche, Timothy Lee, Giorgio Lucigrai, Marco Di Maurizio, Anne Mehl, Anne Munck, Marianne Nuijsink, Jacqueline Payen De La Garanderie, David Rea, Isabelle Sermet, Veronika Skalicka, Florian Streitparth, Philippe Reix, Marleen Smet, Hana Vitouskova

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Progressive cystic fibrosis (CF) lung disease is the main cause of mortality in CF patients. CF lung disease starts in early childhood. With current standards of care, respiratory function remains largely normal in children and more sensitive outcome measures are needed to monitor early CF lung disease. Chest CT is currently the most sensitive imaging modality to monitor pulmonary structural changes in children and adolescents with CF. To quantify structural lung disease reliably among multiple centres, standardisation of chest CT protocols is needed. SCIFI CF (Standardised Chest Imaging Framework for Interventions and Personalised Medicine in CF) was founded to characterise chest CT image quality and radiation doses among 16 participating European CF centres in 10 different countries. We aimed to optimise CT protocols in children and adolescents among several CF centres. A large variety was found in CT protocols, image quality and radiation dose usage among the centres. However, the performance of all CT scanners was found to be very similar, when taking spatial resolution and radiation dose into account. We conclude that multicentre standardisation of chest CT in children and adolescents with CF can be achieved for future clinical trials.

Original language	English
Pages (from-to)	1706-1717
Number of pages	12
Journal	European Respiratory Journal
Volume	47
Issue number	6
DOIs	https://doi.org/10.1183/13993003.01601-2015
Publication status	Published - Jun 1 2016

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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10.1183/13993003.01601-2015

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Kuo, W., Van De Corput, M. P. C. K., Perez-Rovira, A., De Bruijne, M., Fajac, I., Tiddens, H. A. W. M., Van Straten, M., Berteloot, L., De Boeck, K., Braggion, C., Brismar, T. B., Casciaro, R., Cox, D., Davies, J. C., Van Der Ent, C. K., Peña, P. G., Gartner, S., De Graaf, N., Hansell, D., ... Vitouskova, H. (2016). Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis: The way forward. European Respiratory Journal, 47(6), 1706-1717. https://doi.org/10.1183/13993003.01601-2015

Kuo, W, Van De Corput, MPCK, Perez-Rovira, A, De Bruijne, M, Fajac, I, Tiddens, HAWM, Van Straten, M, Berteloot, L, De Boeck, K, Braggion, C, Brismar, TB, Casciaro, R, Cox, D, Davies, JC, Van Der Ent, CK, Peña, PG, Gartner, S, De Graaf, N, Hansell, D, Hjelte, L, Holscher, HC, Jeanes, A, De Jong, PA, Kheniche, A, Lee, T, Lucigrai, G, Di Maurizio, M, Mehl, A, Munck, A, Nuijsink, M, De La Garanderie, JP, Rea, D, Sermet, I, Skalicka, V, Streitparth, F, Reix, P, Smet, M & Vitouskova, H 2016, 'Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis: The way forward', European Respiratory Journal, vol. 47, no. 6, pp. 1706-1717. https://doi.org/10.1183/13993003.01601-2015

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title = "Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis: The way forward",

abstract = "Progressive cystic fibrosis (CF) lung disease is the main cause of mortality in CF patients. CF lung disease starts in early childhood. With current standards of care, respiratory function remains largely normal in children and more sensitive outcome measures are needed to monitor early CF lung disease. Chest CT is currently the most sensitive imaging modality to monitor pulmonary structural changes in children and adolescents with CF. To quantify structural lung disease reliably among multiple centres, standardisation of chest CT protocols is needed. SCIFI CF (Standardised Chest Imaging Framework for Interventions and Personalised Medicine in CF) was founded to characterise chest CT image quality and radiation doses among 16 participating European CF centres in 10 different countries. We aimed to optimise CT protocols in children and adolescents among several CF centres. A large variety was found in CT protocols, image quality and radiation dose usage among the centres. However, the performance of all CT scanners was found to be very similar, when taking spatial resolution and radiation dose into account. We conclude that multicentre standardisation of chest CT in children and adolescents with CF can be achieved for future clinical trials.",

author = "Wieying Kuo and {Van De Corput}, {Mariette P C Kemner} and Adria Perez-Rovira and {De Bruijne}, Marleen and Isabelle Fajac and Tiddens, {Harm A W M} and {Van Straten}, Marcel and Laureline Berteloot and {De Boeck}, Kris and Cesare Braggion and Brismar, {Torkel B.} and Rosaria Casciaro and Desmond Cox and Davies, {Jane C.} and {Van Der Ent}, {C. Kors} and Pe{\~n}a, {Pilar Garcia} and Silvia Gartner and {De Graaf}, Nanko and David Hansell and Lena Hjelte and Holscher, {Herma C.} and Annmarie Jeanes and {De Jong}, {Pim A.} and Ahmed Kheniche and Timothy Lee and Giorgio Lucigrai and {Di Maurizio}, Marco and Anne Mehl and Anne Munck and Marianne Nuijsink and {De La Garanderie}, {Jacqueline Payen} and David Rea and Isabelle Sermet and Veronika Skalicka and Florian Streitparth and Philippe Reix and Marleen Smet and Hana Vitouskova",

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T1 - Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis

T2 - The way forward

AU - Kuo, Wieying

AU - Van De Corput, Mariette P C Kemner

AU - Perez-Rovira, Adria

AU - De Bruijne, Marleen

AU - Fajac, Isabelle

AU - Tiddens, Harm A W M

AU - Van Straten, Marcel

AU - Berteloot, Laureline

AU - De Boeck, Kris

AU - Braggion, Cesare

AU - Brismar, Torkel B.

AU - Casciaro, Rosaria

AU - Cox, Desmond

AU - Davies, Jane C.

AU - Van Der Ent, C. Kors

AU - Peña, Pilar Garcia

AU - Gartner, Silvia

AU - De Graaf, Nanko

AU - Hansell, David

AU - Hjelte, Lena

AU - Holscher, Herma C.

AU - Jeanes, Annmarie

AU - De Jong, Pim A.

AU - Kheniche, Ahmed

AU - Lee, Timothy

AU - Lucigrai, Giorgio

AU - Di Maurizio, Marco

AU - Mehl, Anne

AU - Munck, Anne

AU - Nuijsink, Marianne

AU - De La Garanderie, Jacqueline Payen

AU - Rea, David

AU - Sermet, Isabelle

AU - Skalicka, Veronika

AU - Streitparth, Florian

AU - Reix, Philippe

AU - Smet, Marleen

AU - Vitouskova, Hana

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Progressive cystic fibrosis (CF) lung disease is the main cause of mortality in CF patients. CF lung disease starts in early childhood. With current standards of care, respiratory function remains largely normal in children and more sensitive outcome measures are needed to monitor early CF lung disease. Chest CT is currently the most sensitive imaging modality to monitor pulmonary structural changes in children and adolescents with CF. To quantify structural lung disease reliably among multiple centres, standardisation of chest CT protocols is needed. SCIFI CF (Standardised Chest Imaging Framework for Interventions and Personalised Medicine in CF) was founded to characterise chest CT image quality and radiation doses among 16 participating European CF centres in 10 different countries. We aimed to optimise CT protocols in children and adolescents among several CF centres. A large variety was found in CT protocols, image quality and radiation dose usage among the centres. However, the performance of all CT scanners was found to be very similar, when taking spatial resolution and radiation dose into account. We conclude that multicentre standardisation of chest CT in children and adolescents with CF can be achieved for future clinical trials.

AB - Progressive cystic fibrosis (CF) lung disease is the main cause of mortality in CF patients. CF lung disease starts in early childhood. With current standards of care, respiratory function remains largely normal in children and more sensitive outcome measures are needed to monitor early CF lung disease. Chest CT is currently the most sensitive imaging modality to monitor pulmonary structural changes in children and adolescents with CF. To quantify structural lung disease reliably among multiple centres, standardisation of chest CT protocols is needed. SCIFI CF (Standardised Chest Imaging Framework for Interventions and Personalised Medicine in CF) was founded to characterise chest CT image quality and radiation doses among 16 participating European CF centres in 10 different countries. We aimed to optimise CT protocols in children and adolescents among several CF centres. A large variety was found in CT protocols, image quality and radiation dose usage among the centres. However, the performance of all CT scanners was found to be very similar, when taking spatial resolution and radiation dose into account. We conclude that multicentre standardisation of chest CT in children and adolescents with CF can be achieved for future clinical trials.

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JO - European Journal of Respiratory Diseases

JF - European Journal of Respiratory Diseases

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ER -

Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis: The way forward

Abstract

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