Multicentre chest computed tomography standardisation in children and adolescents with cystic fibrosis: The way forward

Wieying Kuo, Mariette P C Kemner Van De Corput, Adria Perez-Rovira, Marleen De Bruijne, Isabelle Fajac, Harm A W M Tiddens, Marcel Van Straten, Laureline Berteloot, Kris De Boeck, Cesare Braggion, Torkel B. Brismar, Rosaria Casciaro, Desmond Cox, Jane C. Davies, C. Kors Van Der Ent, Pilar Garcia Peña, Silvia Gartner, Nanko De Graaf, David Hansell, Lena HjelteHerma C. Holscher, Annmarie Jeanes, Pim A. De Jong, Ahmed Kheniche, Timothy Lee, Giorgio Lucigrai, Marco Di Maurizio, Anne Mehl, Anne Munck, Marianne Nuijsink, Jacqueline Payen De La Garanderie, David Rea, Isabelle Sermet, Veronika Skalicka, Florian Streitparth, Philippe Reix, Marleen Smet, Hana Vitouskova

Research output: Contribution to journalArticlepeer-review


Progressive cystic fibrosis (CF) lung disease is the main cause of mortality in CF patients. CF lung disease starts in early childhood. With current standards of care, respiratory function remains largely normal in children and more sensitive outcome measures are needed to monitor early CF lung disease. Chest CT is currently the most sensitive imaging modality to monitor pulmonary structural changes in children and adolescents with CF. To quantify structural lung disease reliably among multiple centres, standardisation of chest CT protocols is needed. SCIFI CF (Standardised Chest Imaging Framework for Interventions and Personalised Medicine in CF) was founded to characterise chest CT image quality and radiation doses among 16 participating European CF centres in 10 different countries. We aimed to optimise CT protocols in children and adolescents among several CF centres. A large variety was found in CT protocols, image quality and radiation dose usage among the centres. However, the performance of all CT scanners was found to be very similar, when taking spatial resolution and radiation dose into account. We conclude that multicentre standardisation of chest CT in children and adolescents with CF can be achieved for future clinical trials.

Original languageEnglish
Pages (from-to)1706-1717
Number of pages12
JournalEuropean Respiratory Journal
Issue number6
Publication statusPublished - Jun 1 2016

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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