Multicenter comparative multimodality surveillance of women at genetic-familial high risk for breast cancer (HIBCRIT Study): Interim results

Francesco Sardanelli; Franca Podo; Giuliano D'Agnolo; Arduino Verdecchia; Mariano Santaquilani; Renato Musumeci; Giovanna Trecate; Siranoush Manoukian; Sandro Morassut; Clelia de Giacomi; Massimo Federico; Laura Cortesi; Stefano Corcione; Stefano Cirillo; Vincenzo Marra; Anna Cilotti; Cosimo Di Maggio; Alfonso Fausto; Lorenzo Preda; Chiara Zuiani; Alma Contegiacomo; Antonio Orlacchio; Massimo Calabrese; Lorenzo Bonomo; Ernesto Di Cesare; Maura Tonutti; Pietro Panizza; Alessandro Del Maschio; Silvana Bergonzi; Claudia Costa; Claudio Ferranti; Monica Marchesini; Gianfranco Scaperotta; Laura Suman; Daniele Vergnaghi; Riccardo Dolcetti; Alessandra Viel; Silvia Venturini; Renato Romagnoli; Rachele Battista; Barbara Canossi; Mario de Santis; Isabella Marchi; Veronica Medici; Daniela Turchetti; Patrizia Querzoli; Lisa Cellini; Laura Martincich; Daniele Regge; Carlo Bartolozzi; Generoso Bevilacqua; Isa Brunetti; Maria Adelaide Caligo; Claudia Giaconi; Chiara Iacconi; Dionisa Mazzotta; Monica Moretti; Manuela Roncella; Grazia Artioli; Emma D'Andrea; Gianni Nardelli; Maria Ornella Nicoletto; Luigi Pescarini; Giorgio Zavagno; Bijan Babaei; Francesco Gerra; Adamo Magaldi; Andrea Iozzelli; Eleonora N. Lupo; Michela Russo; Monica Barile; Luca Bazzi; Enrico Cassano; Andrea Decensi; Massimo Bellomi; Bernardo Bonanni; Irene Feroce; Gaetano Villa; Massimo Bazzocchi; Alexia Bestagno; Giuliana Francescutti; Matilde Pensabene; Ida Capuano; Davide Brizzi; Pasquale Battista; Alessandro Cama; Alessandro Carriero; Renato Mariani-Costantini; Giandomenico Palka; Antonietta Ciccozzi; Franco Colista; Caterina Fiumara; Silvia Lelli; Maria Mancini; Carlo Masciocchi; Enrico Ricevuto; Antonio Amoroso; Carla Dellach; Giorgio Mustacchi; Roberto Pozzi-Mucelli; Angela De Gaspari; Isabella Fedele

doi:10.1148/radiol.2423051965

Multicenter comparative multimodality surveillance of women at genetic-familial high risk for breast cancer (HIBCRIT Study): Interim results

Francesco Sardanelli, Franca Podo, Giuliano D'Agnolo, Arduino Verdecchia, Mariano Santaquilani, Renato Musumeci, Giovanna Trecate, Siranoush Manoukian, Sandro Morassut, Clelia de Giacomi, Massimo Federico, Laura Cortesi, Stefano Corcione, Stefano Cirillo, Vincenzo Marra, Anna Cilotti, Cosimo Di Maggio, Alfonso Fausto, Lorenzo Preda, Chiara ZuianiAlma Contegiacomo, Antonio Orlacchio, Massimo Calabrese, Lorenzo Bonomo, Ernesto Di Cesare, Maura Tonutti, Pietro Panizza, Alessandro Del Maschio, Silvana Bergonzi, Claudia Costa, Claudio Ferranti, Monica Marchesini, Gianfranco Scaperotta, Laura Suman, Daniele Vergnaghi, Riccardo Dolcetti, Alessandra Viel, Silvia Venturini, Renato Romagnoli, Rachele Battista, Barbara Canossi, Mario de Santis, Isabella Marchi, Veronica Medici, Daniela Turchetti, Patrizia Querzoli, Lisa Cellini, Laura Martincich, Daniele Regge, Carlo Bartolozzi, Generoso Bevilacqua, Isa Brunetti, Maria Adelaide Caligo, Claudia Giaconi, Chiara Iacconi, Dionisa Mazzotta, Monica Moretti, Manuela Roncella, Grazia Artioli, Emma D'Andrea, Gianni Nardelli, Maria Ornella Nicoletto, Luigi Pescarini, Giorgio Zavagno, Bijan Babaei, Francesco Gerra, Adamo Magaldi, Andrea Iozzelli, Eleonora N. Lupo, Michela Russo, Monica Barile, Luca Bazzi, Enrico Cassano, Andrea Decensi, Massimo Bellomi, Bernardo Bonanni, Irene Feroce, Gaetano Villa, Massimo Bazzocchi, Alexia Bestagno, Giuliana Francescutti, Matilde Pensabene, Ida Capuano, Davide Brizzi, Pasquale Battista, Alessandro Cama, Alessandro Carriero, Renato Mariani-Costantini, Giandomenico Palka, Antonietta Ciccozzi, Franco Colista, Caterina Fiumara, Silvia Lelli, Maria Mancini, Carlo Masciocchi, Enrico Ricevuto, Antonio Amoroso, Carla Dellach, Giorgio Mustacchi, Roberto Pozzi-Mucelli, Angela De Gaspari, Isabella Fedele

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To prospectively compare clinical breast examination (CBE), mammography, ultrasonography (US), and contrast material-enhanced magnetic resonance (MR) imaging for screening women at genetic-familial high risk for breast cancer and report interim results, with pathologic finding as standard. Materials and Methods: Institutional review board of each center approved the research; informed written consent was obtained. CBE, mammography, US, and MR imaging were performed for yearly screening of BRCA1 or BRCA2 mutation carriers, first-degree relatives of BRCA1 or BRCA2 mutation carriers, or women enrolled because of a strong family history of breast or ovarian cancer (three or more events in first-or second-degree relatives in either maternal or paternal line; these included breast cancer in women younger than 60 years, ovarian cancer at any age, and male breast cancer at any age). Results: Two hundred seventy-eight women (mean age, 46 years ± 12 [standard deviation]) were enrolled. Breast cancer was found in 11 of 278 women at first round and seven of 99 at second round (14 invasive, four intraductal; eight were ≤10 mm in diameter). Detection rate per year was 4.8% (18 of 377) overall; 4.3% (11 of 258) in BHCA1 or BRCA2 mutation carriers and first-degree relatives of BRCA1 or BRCA2 mutation carriers versus 5.9% (seven of 119) in women enrolled because of strong family history; and 5.3% (nine of 169) in women with previous personal breast and/or ovarian cancer versus 4.3% (nine of 208) in those without. In six (33%) of 18 patients, cancer was detected only with MR imaging. Sensitivity was as follows: CBE, 50% (95% confidence interval [CI]: 29%, 71%); mammography, 59% (95% CI: 36%, 78%); US, 65% (95% CI: 41%, 83%); and MR imaging, 94% (95% CI: 82%, 99%). Positive predictive value was as follows: CBE, 82% (95% CI: 52%, 93%); mammography, 77% (95% CI: 50%, 92%); US, 65% (95% CI: 41%, 83%); and MR imaging, 63% (95% CI: 43%, 79%). Conclusion: Addition of MR imaging to the screening regimen for high-risk women may enable detection of otherwise unsuspected breast cancers.

Original language	English
Pages (from-to)	698-715
Number of pages	18
Journal	Radiology
Volume	242
Issue number	3
DOIs	https://doi.org/10.1148/radiol.2423051965
Publication status	Published - Mar 2007

ASJC Scopus subject areas

Radiological and Ultrasound Technology

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10.1148/radiol.2423051965

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Sardanelli, F., Podo, F., D'Agnolo, G., Verdecchia, A., Santaquilani, M., Musumeci, R., Trecate, G., Manoukian, S., Morassut, S., de Giacomi, C., Federico, M., Cortesi, L., Corcione, S., Cirillo, S., Marra, V., Cilotti, A., Di Maggio, C., Fausto, A., Preda, L., ... Fedele, I. (2007). Multicenter comparative multimodality surveillance of women at genetic-familial high risk for breast cancer (HIBCRIT Study): Interim results. Radiology, 242(3), 698-715. https://doi.org/10.1148/radiol.2423051965

Sardanelli, F, Podo, F, D'Agnolo, G, Verdecchia, A, Santaquilani, M, Musumeci, R, Trecate, G , Manoukian, S, Morassut, S, de Giacomi, C, Federico, M, Cortesi, L, Corcione, S, Cirillo, S, Marra, V, Cilotti, A, Di Maggio, C, Fausto, A, Preda, L, Zuiani, C, Contegiacomo, A, Orlacchio, A, Calabrese, M, Bonomo, L, Di Cesare, E, Tonutti, M, Panizza, P , Del Maschio, A, Bergonzi, S, Costa, C, Ferranti, C, Marchesini, M, Scaperotta, G, Suman, L, Vergnaghi, D, Dolcetti, R, Viel, A, Venturini, S, Romagnoli, R, Battista, R, Canossi, B, de Santis, M, Marchi, I, Medici, V, Turchetti, D, Querzoli, P, Cellini, L, Martincich, L, Regge, D, Bartolozzi, C, Bevilacqua, G, Brunetti, I, Caligo, MA, Giaconi, C, Iacconi, C, Mazzotta, D, Moretti, M, Roncella, M, Artioli, G, D'Andrea, E, Nardelli, G, Nicoletto, MO, Pescarini, L, Zavagno, G, Babaei, B, Gerra, F, Magaldi, A, Iozzelli, A, Lupo, EN, Russo, M, Barile, M, Bazzi, L, Cassano, E, Decensi, A, Bellomi, M, Bonanni, B , Feroce, I, Villa, G, Bazzocchi, M, Bestagno, A, Francescutti, G, Pensabene, M, Capuano, I, Brizzi, D, Battista, P, Cama, A, Carriero, A, Mariani-Costantini, R, Palka, G, Ciccozzi, A, Colista, F, Fiumara, C, Lelli, S, Mancini, M, Masciocchi, C, Ricevuto, E, Amoroso, A, Dellach, C, Mustacchi, G, Pozzi-Mucelli, R, De Gaspari, A & Fedele, I 2007, 'Multicenter comparative multimodality surveillance of women at genetic-familial high risk for breast cancer (HIBCRIT Study): Interim results', Radiology, vol. 242, no. 3, pp. 698-715. https://doi.org/10.1148/radiol.2423051965

@article{1bd8067dae5b400b9fc4115f1b2a7147,

title = "Multicenter comparative multimodality surveillance of women at genetic-familial high risk for breast cancer (HIBCRIT Study): Interim results",

abstract = "Purpose: To prospectively compare clinical breast examination (CBE), mammography, ultrasonography (US), and contrast material-enhanced magnetic resonance (MR) imaging for screening women at genetic-familial high risk for breast cancer and report interim results, with pathologic finding as standard. Materials and Methods: Institutional review board of each center approved the research; informed written consent was obtained. CBE, mammography, US, and MR imaging were performed for yearly screening of BRCA1 or BRCA2 mutation carriers, first-degree relatives of BRCA1 or BRCA2 mutation carriers, or women enrolled because of a strong family history of breast or ovarian cancer (three or more events in first-or second-degree relatives in either maternal or paternal line; these included breast cancer in women younger than 60 years, ovarian cancer at any age, and male breast cancer at any age). Results: Two hundred seventy-eight women (mean age, 46 years ± 12 [standard deviation]) were enrolled. Breast cancer was found in 11 of 278 women at first round and seven of 99 at second round (14 invasive, four intraductal; eight were ≤10 mm in diameter). Detection rate per year was 4.8% (18 of 377) overall; 4.3% (11 of 258) in BHCA1 or BRCA2 mutation carriers and first-degree relatives of BRCA1 or BRCA2 mutation carriers versus 5.9% (seven of 119) in women enrolled because of strong family history; and 5.3% (nine of 169) in women with previous personal breast and/or ovarian cancer versus 4.3% (nine of 208) in those without. In six (33%) of 18 patients, cancer was detected only with MR imaging. Sensitivity was as follows: CBE, 50% (95% confidence interval [CI]: 29%, 71%); mammography, 59% (95% CI: 36%, 78%); US, 65% (95% CI: 41%, 83%); and MR imaging, 94% (95% CI: 82%, 99%). Positive predictive value was as follows: CBE, 82% (95% CI: 52%, 93%); mammography, 77% (95% CI: 50%, 92%); US, 65% (95% CI: 41%, 83%); and MR imaging, 63% (95% CI: 43%, 79%). Conclusion: Addition of MR imaging to the screening regimen for high-risk women may enable detection of otherwise unsuspected breast cancers.",

author = "Francesco Sardanelli and Franca Podo and Giuliano D'Agnolo and Arduino Verdecchia and Mariano Santaquilani and Renato Musumeci and Giovanna Trecate and Siranoush Manoukian and Sandro Morassut and {de Giacomi}, Clelia and Massimo Federico and Laura Cortesi and Stefano Corcione and Stefano Cirillo and Vincenzo Marra and Anna Cilotti and {Di Maggio}, Cosimo and Alfonso Fausto and Lorenzo Preda and Chiara Zuiani and Alma Contegiacomo and Antonio Orlacchio and Massimo Calabrese and Lorenzo Bonomo and {Di Cesare}, Ernesto and Maura Tonutti and Pietro Panizza and {Del Maschio}, Alessandro and Silvana Bergonzi and Claudia Costa and Claudio Ferranti and Monica Marchesini and Gianfranco Scaperotta and Laura Suman and Daniele Vergnaghi and Riccardo Dolcetti and Alessandra Viel and Silvia Venturini and Renato Romagnoli and Rachele Battista and Barbara Canossi and {de Santis}, Mario and Isabella Marchi and Veronica Medici and Daniela Turchetti and Patrizia Querzoli and Lisa Cellini and Laura Martincich and Daniele Regge and Carlo Bartolozzi and Generoso Bevilacqua and Isa Brunetti and Caligo, {Maria Adelaide} and Claudia Giaconi and Chiara Iacconi and Dionisa Mazzotta and Monica Moretti and Manuela Roncella and Grazia Artioli and Emma D'Andrea and Gianni Nardelli and Nicoletto, {Maria Ornella} and Luigi Pescarini and Giorgio Zavagno and Bijan Babaei and Francesco Gerra and Adamo Magaldi and Andrea Iozzelli and Lupo, {Eleonora N.} and Michela Russo and Monica Barile and Luca Bazzi and Enrico Cassano and Andrea Decensi and Massimo Bellomi and Bernardo Bonanni and Irene Feroce and Gaetano Villa and Massimo Bazzocchi and Alexia Bestagno and Giuliana Francescutti and Matilde Pensabene and Ida Capuano and Davide Brizzi and Pasquale Battista and Alessandro Cama and Alessandro Carriero and Renato Mariani-Costantini and Giandomenico Palka and Antonietta Ciccozzi and Franco Colista and Caterina Fiumara and Silvia Lelli and Maria Mancini and Carlo Masciocchi and Enrico Ricevuto and Antonio Amoroso and Carla Dellach and Giorgio Mustacchi and Roberto Pozzi-Mucelli and {De Gaspari}, Angela and Isabella Fedele",

year = "2007",

month = mar,

doi = "10.1148/radiol.2423051965",

language = "English",

volume = "242",

pages = "698--715",

journal = "Radiology",

issn = "0033-8419",

publisher = "Radiological Society of North America Inc.",

number = "3",

}

TY - JOUR

T1 - Multicenter comparative multimodality surveillance of women at genetic-familial high risk for breast cancer (HIBCRIT Study)

T2 - Interim results

AU - Sardanelli, Francesco

AU - Podo, Franca

AU - D'Agnolo, Giuliano

AU - Verdecchia, Arduino

AU - Santaquilani, Mariano

AU - Musumeci, Renato

AU - Trecate, Giovanna

AU - Manoukian, Siranoush

AU - Morassut, Sandro

AU - de Giacomi, Clelia

AU - Federico, Massimo

AU - Cortesi, Laura

AU - Corcione, Stefano

AU - Cirillo, Stefano

AU - Marra, Vincenzo

AU - Cilotti, Anna

AU - Di Maggio, Cosimo

AU - Fausto, Alfonso

AU - Preda, Lorenzo

AU - Zuiani, Chiara

AU - Contegiacomo, Alma

AU - Orlacchio, Antonio

AU - Calabrese, Massimo

AU - Bonomo, Lorenzo

AU - Di Cesare, Ernesto

AU - Tonutti, Maura

AU - Panizza, Pietro

AU - Del Maschio, Alessandro

AU - Bergonzi, Silvana

AU - Costa, Claudia

AU - Ferranti, Claudio

AU - Marchesini, Monica

AU - Scaperotta, Gianfranco

AU - Suman, Laura

AU - Vergnaghi, Daniele

AU - Dolcetti, Riccardo

AU - Viel, Alessandra

AU - Venturini, Silvia

AU - Romagnoli, Renato

AU - Battista, Rachele

AU - Canossi, Barbara

AU - de Santis, Mario

AU - Marchi, Isabella

AU - Medici, Veronica

AU - Turchetti, Daniela

AU - Querzoli, Patrizia

AU - Cellini, Lisa

AU - Martincich, Laura

AU - Regge, Daniele

AU - Bartolozzi, Carlo

AU - Bevilacqua, Generoso

AU - Brunetti, Isa

AU - Caligo, Maria Adelaide

AU - Giaconi, Claudia

AU - Iacconi, Chiara

AU - Mazzotta, Dionisa

AU - Moretti, Monica

AU - Roncella, Manuela

AU - Artioli, Grazia

AU - D'Andrea, Emma

AU - Nardelli, Gianni

AU - Nicoletto, Maria Ornella

AU - Pescarini, Luigi

AU - Zavagno, Giorgio

AU - Babaei, Bijan

AU - Gerra, Francesco

AU - Magaldi, Adamo

AU - Iozzelli, Andrea

AU - Lupo, Eleonora N.

AU - Russo, Michela

AU - Barile, Monica

AU - Bazzi, Luca

AU - Cassano, Enrico

AU - Decensi, Andrea

AU - Bellomi, Massimo

AU - Bonanni, Bernardo

AU - Feroce, Irene

AU - Villa, Gaetano

AU - Bazzocchi, Massimo

AU - Bestagno, Alexia

AU - Francescutti, Giuliana

AU - Pensabene, Matilde

AU - Capuano, Ida

AU - Brizzi, Davide

AU - Battista, Pasquale

AU - Cama, Alessandro

AU - Carriero, Alessandro

AU - Mariani-Costantini, Renato

AU - Palka, Giandomenico

AU - Ciccozzi, Antonietta

AU - Colista, Franco

AU - Fiumara, Caterina

AU - Lelli, Silvia

AU - Mancini, Maria

AU - Masciocchi, Carlo

AU - Ricevuto, Enrico

AU - Amoroso, Antonio

AU - Dellach, Carla

AU - Mustacchi, Giorgio

AU - Pozzi-Mucelli, Roberto

AU - De Gaspari, Angela

AU - Fedele, Isabella

PY - 2007/3

Y1 - 2007/3

N2 - Purpose: To prospectively compare clinical breast examination (CBE), mammography, ultrasonography (US), and contrast material-enhanced magnetic resonance (MR) imaging for screening women at genetic-familial high risk for breast cancer and report interim results, with pathologic finding as standard. Materials and Methods: Institutional review board of each center approved the research; informed written consent was obtained. CBE, mammography, US, and MR imaging were performed for yearly screening of BRCA1 or BRCA2 mutation carriers, first-degree relatives of BRCA1 or BRCA2 mutation carriers, or women enrolled because of a strong family history of breast or ovarian cancer (three or more events in first-or second-degree relatives in either maternal or paternal line; these included breast cancer in women younger than 60 years, ovarian cancer at any age, and male breast cancer at any age). Results: Two hundred seventy-eight women (mean age, 46 years ± 12 [standard deviation]) were enrolled. Breast cancer was found in 11 of 278 women at first round and seven of 99 at second round (14 invasive, four intraductal; eight were ≤10 mm in diameter). Detection rate per year was 4.8% (18 of 377) overall; 4.3% (11 of 258) in BHCA1 or BRCA2 mutation carriers and first-degree relatives of BRCA1 or BRCA2 mutation carriers versus 5.9% (seven of 119) in women enrolled because of strong family history; and 5.3% (nine of 169) in women with previous personal breast and/or ovarian cancer versus 4.3% (nine of 208) in those without. In six (33%) of 18 patients, cancer was detected only with MR imaging. Sensitivity was as follows: CBE, 50% (95% confidence interval [CI]: 29%, 71%); mammography, 59% (95% CI: 36%, 78%); US, 65% (95% CI: 41%, 83%); and MR imaging, 94% (95% CI: 82%, 99%). Positive predictive value was as follows: CBE, 82% (95% CI: 52%, 93%); mammography, 77% (95% CI: 50%, 92%); US, 65% (95% CI: 41%, 83%); and MR imaging, 63% (95% CI: 43%, 79%). Conclusion: Addition of MR imaging to the screening regimen for high-risk women may enable detection of otherwise unsuspected breast cancers.

AB - Purpose: To prospectively compare clinical breast examination (CBE), mammography, ultrasonography (US), and contrast material-enhanced magnetic resonance (MR) imaging for screening women at genetic-familial high risk for breast cancer and report interim results, with pathologic finding as standard. Materials and Methods: Institutional review board of each center approved the research; informed written consent was obtained. CBE, mammography, US, and MR imaging were performed for yearly screening of BRCA1 or BRCA2 mutation carriers, first-degree relatives of BRCA1 or BRCA2 mutation carriers, or women enrolled because of a strong family history of breast or ovarian cancer (three or more events in first-or second-degree relatives in either maternal or paternal line; these included breast cancer in women younger than 60 years, ovarian cancer at any age, and male breast cancer at any age). Results: Two hundred seventy-eight women (mean age, 46 years ± 12 [standard deviation]) were enrolled. Breast cancer was found in 11 of 278 women at first round and seven of 99 at second round (14 invasive, four intraductal; eight were ≤10 mm in diameter). Detection rate per year was 4.8% (18 of 377) overall; 4.3% (11 of 258) in BHCA1 or BRCA2 mutation carriers and first-degree relatives of BRCA1 or BRCA2 mutation carriers versus 5.9% (seven of 119) in women enrolled because of strong family history; and 5.3% (nine of 169) in women with previous personal breast and/or ovarian cancer versus 4.3% (nine of 208) in those without. In six (33%) of 18 patients, cancer was detected only with MR imaging. Sensitivity was as follows: CBE, 50% (95% confidence interval [CI]: 29%, 71%); mammography, 59% (95% CI: 36%, 78%); US, 65% (95% CI: 41%, 83%); and MR imaging, 94% (95% CI: 82%, 99%). Positive predictive value was as follows: CBE, 82% (95% CI: 52%, 93%); mammography, 77% (95% CI: 50%, 92%); US, 65% (95% CI: 41%, 83%); and MR imaging, 63% (95% CI: 43%, 79%). Conclusion: Addition of MR imaging to the screening regimen for high-risk women may enable detection of otherwise unsuspected breast cancers.

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U2 - 10.1148/radiol.2423051965

DO - 10.1148/radiol.2423051965

M3 - Article

C2 - 17244718

AN - SCOPUS:33847195712

SN - 0033-8419

VL - 242

SP - 698

EP - 715

JO - Radiology

JF - Radiology

IS - 3

ER -

Multicenter comparative multimodality surveillance of women at genetic-familial high risk for breast cancer (HIBCRIT Study): Interim results

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