Multi-omic profiling of MYCN-amplified neuroblastoma cell-lines

Erik Dassi, Valentina Greco, Viktoryia Sidarovich, Paola Zuccotti, Natalia Arseni, Paola Scaruffi, Gian Paolo Tonini, Alessandro Quattrone

Research output: Contribution to journalArticlepeer-review


Neuroblastoma is the most common pediatric cancer, arising from the neural crest cells of the sympathetic nervous system. Its most aggressive subtype, characterized by the amplification of the MYCN oncogene, has a dismal prognosis and no effective treatment is available. Understanding the alterations induced by the tumor on the various layers of gene expression is therefore important for a complete characterization of this neuroblastoma subtype and for the discovery of new therapeutic opportunities. Here we describe the profiling of 13 MYCN-amplified neuroblastoma cell lines at the genome (copy number), transcriptome, translatome and miRome levels (GEO series GSE56654, GSE56552 and GSE56655). We provide detailed experimental and data analysis procedures by means of which we derived the results described in [1].

Original languageEnglish
Pages (from-to)285-287
Number of pages3
JournalGenomics Data
Publication statusPublished - Dec 1 2015


  • Copy-number
  • MiRome
  • Neuroblastoma
  • Transcriptome
  • Translatome

ASJC Scopus subject areas

  • Molecular Medicine
  • Biochemistry
  • Biotechnology
  • Genetics


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