Multi-omic profiling of MYCN-amplified neuroblastoma cell-lines

Erik Dassi; Valentina Greco; Viktoryia Sidarovich; Paola Zuccotti; Natalia Arseni; Paola Scaruffi; Gian Paolo Tonini; Alessandro Quattrone

doi:10.1016/j.gdata.2015.11.012

Multi-omic profiling of MYCN-amplified neuroblastoma cell-lines

Erik Dassi, Valentina Greco, Viktoryia Sidarovich, Paola Zuccotti, Natalia Arseni, Paola Scaruffi, Gian Paolo Tonini, Alessandro Quattrone

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Neuroblastoma is the most common pediatric cancer, arising from the neural crest cells of the sympathetic nervous system. Its most aggressive subtype, characterized by the amplification of the MYCN oncogene, has a dismal prognosis and no effective treatment is available. Understanding the alterations induced by the tumor on the various layers of gene expression is therefore important for a complete characterization of this neuroblastoma subtype and for the discovery of new therapeutic opportunities. Here we describe the profiling of 13 MYCN-amplified neuroblastoma cell lines at the genome (copy number), transcriptome, translatome and miRome levels (GEO series GSE56654, GSE56552 and GSE56655). We provide detailed experimental and data analysis procedures by means of which we derived the results described in [1].

Original language	English
Pages (from-to)	285-287
Number of pages	3
Journal	Genomics Data
Volume	6
DOIs	https://doi.org/10.1016/j.gdata.2015.11.012
Publication status	Published - Dec 1 2015

Keywords

Copy-number
MiRome
Neuroblastoma
Transcriptome
Translatome

ASJC Scopus subject areas

Molecular Medicine
Biochemistry
Biotechnology
Genetics

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10.1016/j.gdata.2015.11.012

Cite this

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title = "Multi-omic profiling of MYCN-amplified neuroblastoma cell-lines",

abstract = "Neuroblastoma is the most common pediatric cancer, arising from the neural crest cells of the sympathetic nervous system. Its most aggressive subtype, characterized by the amplification of the MYCN oncogene, has a dismal prognosis and no effective treatment is available. Understanding the alterations induced by the tumor on the various layers of gene expression is therefore important for a complete characterization of this neuroblastoma subtype and for the discovery of new therapeutic opportunities. Here we describe the profiling of 13 MYCN-amplified neuroblastoma cell lines at the genome (copy number), transcriptome, translatome and miRome levels (GEO series GSE56654, GSE56552 and GSE56655). We provide detailed experimental and data analysis procedures by means of which we derived the results described in [1].",

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author = "Erik Dassi and Valentina Greco and Viktoryia Sidarovich and Paola Zuccotti and Natalia Arseni and Paola Scaruffi and Tonini, {Gian Paolo} and Alessandro Quattrone",

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T1 - Multi-omic profiling of MYCN-amplified neuroblastoma cell-lines

AU - Dassi, Erik

AU - Greco, Valentina

AU - Sidarovich, Viktoryia

AU - Zuccotti, Paola

AU - Arseni, Natalia

AU - Scaruffi, Paola

AU - Tonini, Gian Paolo

AU - Quattrone, Alessandro

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Neuroblastoma is the most common pediatric cancer, arising from the neural crest cells of the sympathetic nervous system. Its most aggressive subtype, characterized by the amplification of the MYCN oncogene, has a dismal prognosis and no effective treatment is available. Understanding the alterations induced by the tumor on the various layers of gene expression is therefore important for a complete characterization of this neuroblastoma subtype and for the discovery of new therapeutic opportunities. Here we describe the profiling of 13 MYCN-amplified neuroblastoma cell lines at the genome (copy number), transcriptome, translatome and miRome levels (GEO series GSE56654, GSE56552 and GSE56655). We provide detailed experimental and data analysis procedures by means of which we derived the results described in [1].

AB - Neuroblastoma is the most common pediatric cancer, arising from the neural crest cells of the sympathetic nervous system. Its most aggressive subtype, characterized by the amplification of the MYCN oncogene, has a dismal prognosis and no effective treatment is available. Understanding the alterations induced by the tumor on the various layers of gene expression is therefore important for a complete characterization of this neuroblastoma subtype and for the discovery of new therapeutic opportunities. Here we describe the profiling of 13 MYCN-amplified neuroblastoma cell lines at the genome (copy number), transcriptome, translatome and miRome levels (GEO series GSE56654, GSE56552 and GSE56655). We provide detailed experimental and data analysis procedures by means of which we derived the results described in [1].

KW - Copy-number

KW - MiRome

KW - Neuroblastoma

KW - Transcriptome

KW - Translatome

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JF - Genomics Data

ER -

Multi-omic profiling of MYCN-amplified neuroblastoma cell-lines

Abstract

Keywords

ASJC Scopus subject areas

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