Multi-field-of-view SPECT is superior to whole-body scanning for assessing metastatic bone disease in patients with prostate cancer

Luca Giovanella; Massimo Castellani; Sergio Suriano; Teresa Ruberto; Luca Ceriani; Luca Tagliabue; Giovanni Lucignani

Multi-field-of-view SPECT is superior to whole-body scanning for assessing metastatic bone disease in patients with prostate cancer

Luca Giovanella, Massimo Castellani, Sergio Suriano, Teresa Ruberto, Luca Ceriani, Luca Tagliabue, Giovanni Lucignani

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Aim. The aimof this study was to compare the diagnostic performance of whole-body bone scintigraphy (WBS) and multi-field-of-view single photon emission tomography (multi-FOV SPECT) with ^99mTc-oxidronate ( ^99mTc-HDP) in patients with prostate cancer (PCa). Methods. In a prospective study, WBS and SPECT acquisitions were performed in 194 patients with histologically confirmed PCa and serumprostate-specific antigen (PSA) levels above 10 ng/mL. Scans obtained using the two modalities were interpreted separately. Clinical and biochemical follow-up, radiological studies and biopsies served as benchmarks for the assessments. The impact of PSA level on WBS and SPECT results was also evaluated. Results. The patient-based sensitivity, specificity, accuracy, PPV and NPV values of SPECT examinations were higher than those of WBS, especially in patients with serum PSA levels

Original language	English
Pages (from-to)	629-633
Number of pages	5
Journal	Tumori
Volume	97
Issue number	5
Publication status	Published - Sept 2011

Keywords

Tc-oxidronate
Bone metastases
Prostate cancer
Single photon emission tomography

ASJC Scopus subject areas

Cancer Research
Oncology

Cite this

@article{1075ce5013874d048e98aa768bc7b816,

title = "Multi-field-of-view SPECT is superior to whole-body scanning for assessing metastatic bone disease in patients with prostate cancer",

abstract = "Aim. The aimof this study was to compare the diagnostic performance of whole-body bone scintigraphy (WBS) and multi-field-of-view single photon emission tomography (multi-FOV SPECT) with 99mTc-oxidronate ( 99mTc-HDP) in patients with prostate cancer (PCa). Methods. In a prospective study, WBS and SPECT acquisitions were performed in 194 patients with histologically confirmed PCa and serumprostate-specific antigen (PSA) levels above 10 ng/mL. Scans obtained using the two modalities were interpreted separately. Clinical and biochemical follow-up, radiological studies and biopsies served as benchmarks for the assessments. The impact of PSA level on WBS and SPECT results was also evaluated. Results. The patient-based sensitivity, specificity, accuracy, PPV and NPV values of SPECT examinations were higher than those of WBS, especially in patients with serum PSA levels ",

keywords = "Tc-oxidronate, Bone metastases, Prostate cancer, Single photon emission tomography",

author = "Luca Giovanella and Massimo Castellani and Sergio Suriano and Teresa Ruberto and Luca Ceriani and Luca Tagliabue and Giovanni Lucignani",

year = "2011",

month = sep,

language = "English",

volume = "97",

pages = "629--633",

journal = "Tumori",

issn = "0300-8916",

publisher = "SAGE Publications Ltd",

number = "5",

}

TY - JOUR

T1 - Multi-field-of-view SPECT is superior to whole-body scanning for assessing metastatic bone disease in patients with prostate cancer

AU - Giovanella, Luca

AU - Castellani, Massimo

AU - Suriano, Sergio

AU - Ruberto, Teresa

AU - Ceriani, Luca

AU - Tagliabue, Luca

AU - Lucignani, Giovanni

PY - 2011/9

Y1 - 2011/9

N2 - Aim. The aimof this study was to compare the diagnostic performance of whole-body bone scintigraphy (WBS) and multi-field-of-view single photon emission tomography (multi-FOV SPECT) with 99mTc-oxidronate ( 99mTc-HDP) in patients with prostate cancer (PCa). Methods. In a prospective study, WBS and SPECT acquisitions were performed in 194 patients with histologically confirmed PCa and serumprostate-specific antigen (PSA) levels above 10 ng/mL. Scans obtained using the two modalities were interpreted separately. Clinical and biochemical follow-up, radiological studies and biopsies served as benchmarks for the assessments. The impact of PSA level on WBS and SPECT results was also evaluated. Results. The patient-based sensitivity, specificity, accuracy, PPV and NPV values of SPECT examinations were higher than those of WBS, especially in patients with serum PSA levels

AB - Aim. The aimof this study was to compare the diagnostic performance of whole-body bone scintigraphy (WBS) and multi-field-of-view single photon emission tomography (multi-FOV SPECT) with 99mTc-oxidronate ( 99mTc-HDP) in patients with prostate cancer (PCa). Methods. In a prospective study, WBS and SPECT acquisitions were performed in 194 patients with histologically confirmed PCa and serumprostate-specific antigen (PSA) levels above 10 ng/mL. Scans obtained using the two modalities were interpreted separately. Clinical and biochemical follow-up, radiological studies and biopsies served as benchmarks for the assessments. The impact of PSA level on WBS and SPECT results was also evaluated. Results. The patient-based sensitivity, specificity, accuracy, PPV and NPV values of SPECT examinations were higher than those of WBS, especially in patients with serum PSA levels

KW - Tc-oxidronate

KW - Bone metastases

KW - Prostate cancer

KW - Single photon emission tomography

UR - http://www.scopus.com/inward/record.url?scp=83055170753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83055170753&partnerID=8YFLogxK

M3 - Article

C2 - 22158495

AN - SCOPUS:83055170753

SN - 0300-8916

VL - 97

SP - 629

EP - 633

JO - Tumori

JF - Tumori

IS - 5

ER -

Multi-field-of-view SPECT is superior to whole-body scanning for assessing metastatic bone disease in patients with prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this