Mucosal Schwann cell "Hamartoma": A new entity?

Paola Pasquini, Andrea Baiocchini, Laura Falasca, Dante Annibali, Guido Gimbo, Francesco Pace, Franca Del Nonno

Research output: Contribution to journalArticlepeer-review


Schwannoma is a well-described, benign nerve sheath tumor of the soft tissue, but is rare in the gastrointestinal tract. Gastrointestinal schwannomas are often incidentally discovered as small polypoid intraluminal lesions. In this report, we describe the clinicopathologic and immunohistochemical features of a distinctive neural mucosal polyp composed of a diffuse cellular proliferation of uniform bland spindled cells in the lamina propria that entraps the colonic crypts. Immunohistochemical analysis revealed strong and diffuse positivity for the S-100 protein. To avoid confusion of these solitary colorectal polyps containing pure spindled Schwann cell proliferation in the lamina propria with neural lesions that have significant association with inherited syndromes, it is better to use the designation "mucosal Schwann hamartoma".

Original languageEnglish
Pages (from-to)2287-2289
Number of pages3
JournalWorld Journal of Gastroenterology
Issue number18
Publication statusPublished - May 14 2009


  • Gastrointestinal Schwannoma
  • Hamartoma
  • Nerve sheath-tumors

ASJC Scopus subject areas

  • Gastroenterology


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