MRI study of corpus callosum in patients with borderline personality disorder. A pilot study

Marcus V. Zanetti, Paul H. Soloff, Mark A. Nicoletti, John P. Hatch, Paolo Brambilla, Matcheri S. Keshavan, Jair C. Soares

Research output: Contribution to journalArticlepeer-review


This pilot study examined the integrity of the corpus callosum in a sample of patients with borderline personality disorder (BPD), as abnormalities in inter-hemispheric communication could possibly be involved in illness pathophysiology. We utilized magnetic resonance imaging (MRI) signal intensity (SI) and morphometric measures. Ten BPD and 20 healthy control subjects were assessed for current and past Axis I and Axis II comorbidities and histories of childhood abuse. Regional CC SI and areas were measured with semi-automated software from three-dimensional gradient echo imaging scans. Analysis of covariance was conducted to evaluate the results. No significant differences were observed between BPD and controls in the SI or area of any CC region. Abnormalities in interhemispheric connectivity do not appear necessary for the development of BPD. Further studies with larger samples are needed to confirm this preliminary finding.

Original languageEnglish
Pages (from-to)1519-1525
Number of pages7
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number7
Publication statusPublished - Oct 1 2007


  • Borderline personality disorder
  • Childhood abuse
  • Corpus callosum
  • Development
  • Magnetic resonance imaging
  • Neuroimaging

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology


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