MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study

Tero Tapiola; Corina Pennanen; Mia Tapiola; Susanna Tervo; Miia Kivipelto; Tuomo Hänninen; Maija Pihlajamäki; Mikko P. Laakso; Merja Hallikainen; Anne Hämäläinen; Matti Vanhanen; Eeva Liisa Helkala; Ritva Vanninen; Aulikki Nissinen; Roberta Rossi; Giovanni B. Frisoni; Hilkka Soininen

doi:10.1016/j.neurobiolaging.2006.09.007

MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study

Tero Tapiola, Corina Pennanen, Mia Tapiola, Susanna Tervo, Miia Kivipelto, Tuomo Hänninen, Maija Pihlajamäki, Mikko P. Laakso, Merja Hallikainen, Anne Hämäläinen, Matti Vanhanen, Eeva Liisa Helkala, Ritva Vanninen, Aulikki Nissinen, Roberta Rossi, Giovanni B. Frisoni, Hilkka Soininen

Centro San Giovanni di Dio - Fatebenefratelli

Research output: Contribution to journal › Article › peer-review

Abstract

The concept of mild cognitive impairment (MCI) has been proposed to represent a transitional stage between normal aging and dementia. We studied the predictive value of the MRI-derived volumes of medial temporal lobe (MTL) structures, white matter lesions (WML), neuropsychological tests, and Apolipoprotein E (APOE) genotype on conversion of MCI to dementia and AD. The study included 60 subjects with MCI identified from population cohorts. During the mean follow-up period of 34 months, 13 patients had progressed to dementia (9 to Alzheimer's disease (AD)). In Cox regression analysis the baseline volumes of the right hippocampus, the right entorhinal cortex and CDR sum of boxes predicted the progression of MCI to dementia during the follow-up. In a bivariate analysis, only the baseline volumes of entorhinal cortex predicted conversion of MCI to AD. The Mini-Mental State Examination (MMSE) score at baseline, WML load, or APOE genotype were not significant predictors of progression. The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD.

Original language	English
Pages (from-to)	31-38
Number of pages	8
Journal	Neurobiology of Aging
Volume	29
Issue number	1
DOIs	https://doi.org/10.1016/j.neurobiolaging.2006.09.007
Publication status	Published - Jan 2008

Keywords

Alzheimer's disease
APOE
Entorhinal cortex
Follow-up study
Hippocampus
Memory
Mild cognitive impairment
MRI
Volumetry
White matter lesions

ASJC Scopus subject areas

Clinical Neurology
Biological Psychiatry
Developmental Neuroscience
Neurology
Psychology(all)

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10.1016/j.neurobiolaging.2006.09.007

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Tapiola, T., Pennanen, C., Tapiola, M., Tervo, S., Kivipelto, M., Hänninen, T., Pihlajamäki, M., Laakso, M. P., Hallikainen, M., Hämäläinen, A., Vanhanen, M., Helkala, E. L., Vanninen, R., Nissinen, A., Rossi, R., Frisoni, G. B., & Soininen, H. (2008). MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study. Neurobiology of Aging, 29(1), 31-38. https://doi.org/10.1016/j.neurobiolaging.2006.09.007

Tapiola, T, Pennanen, C, Tapiola, M, Tervo, S, Kivipelto, M, Hänninen, T, Pihlajamäki, M, Laakso, MP, Hallikainen, M, Hämäläinen, A, Vanhanen, M, Helkala, EL, Vanninen, R, Nissinen, A, Rossi, R, Frisoni, GB & Soininen, H 2008, 'MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study', Neurobiology of Aging, vol. 29, no. 1, pp. 31-38. https://doi.org/10.1016/j.neurobiolaging.2006.09.007

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abstract = "The concept of mild cognitive impairment (MCI) has been proposed to represent a transitional stage between normal aging and dementia. We studied the predictive value of the MRI-derived volumes of medial temporal lobe (MTL) structures, white matter lesions (WML), neuropsychological tests, and Apolipoprotein E (APOE) genotype on conversion of MCI to dementia and AD. The study included 60 subjects with MCI identified from population cohorts. During the mean follow-up period of 34 months, 13 patients had progressed to dementia (9 to Alzheimer's disease (AD)). In Cox regression analysis the baseline volumes of the right hippocampus, the right entorhinal cortex and CDR sum of boxes predicted the progression of MCI to dementia during the follow-up. In a bivariate analysis, only the baseline volumes of entorhinal cortex predicted conversion of MCI to AD. The Mini-Mental State Examination (MMSE) score at baseline, WML load, or APOE genotype were not significant predictors of progression. The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD.",

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AU - Kivipelto, Miia

AU - Hänninen, Tuomo

AU - Pihlajamäki, Maija

AU - Laakso, Mikko P.

AU - Hallikainen, Merja

AU - Hämäläinen, Anne

AU - Vanhanen, Matti

AU - Helkala, Eeva Liisa

AU - Vanninen, Ritva

AU - Nissinen, Aulikki

AU - Rossi, Roberta

AU - Frisoni, Giovanni B.

AU - Soininen, Hilkka

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MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study

Abstract

Keywords

ASJC Scopus subject areas

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