MRI of hippocampus and entorhinal cortex in mild cognitive impairment: A follow-up study

Tero Tapiola, Corina Pennanen, Mia Tapiola, Susanna Tervo, Miia Kivipelto, Tuomo Hänninen, Maija Pihlajamäki, Mikko P. Laakso, Merja Hallikainen, Anne Hämäläinen, Matti Vanhanen, Eeva Liisa Helkala, Ritva Vanninen, Aulikki Nissinen, Roberta Rossi, Giovanni B. Frisoni, Hilkka Soininen

Research output: Contribution to journalArticlepeer-review


The concept of mild cognitive impairment (MCI) has been proposed to represent a transitional stage between normal aging and dementia. We studied the predictive value of the MRI-derived volumes of medial temporal lobe (MTL) structures, white matter lesions (WML), neuropsychological tests, and Apolipoprotein E (APOE) genotype on conversion of MCI to dementia and AD. The study included 60 subjects with MCI identified from population cohorts. During the mean follow-up period of 34 months, 13 patients had progressed to dementia (9 to Alzheimer's disease (AD)). In Cox regression analysis the baseline volumes of the right hippocampus, the right entorhinal cortex and CDR sum of boxes predicted the progression of MCI to dementia during the follow-up. In a bivariate analysis, only the baseline volumes of entorhinal cortex predicted conversion of MCI to AD. The Mini-Mental State Examination (MMSE) score at baseline, WML load, or APOE genotype were not significant predictors of progression. The MTL volumetry helps in identifying among the MCI subjects a group, which is at high risk for developing AD.

Original languageEnglish
Pages (from-to)31-38
Number of pages8
JournalNeurobiology of Aging
Issue number1
Publication statusPublished - Jan 2008


  • Alzheimer's disease
  • APOE
  • Entorhinal cortex
  • Follow-up study
  • Hippocampus
  • Memory
  • Mild cognitive impairment
  • MRI
  • Volumetry
  • White matter lesions

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)


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