TY - JOUR
T1 - Motor events during REM sleep in patients with narcolepsy-cataplexy
T2 - A video-polysomnographic pilot study
AU - Franceschini, Christian
AU - Ferri, Raffaele
AU - Pizza, Fabio
AU - Ricotta, Lara
AU - Vandi, Stefano
AU - Detto, Stefania
AU - Poli, Francesca
AU - Pruneti, Carlo
AU - Mazzetti, Michela
AU - Cipolli, Carlo
AU - Lugaresi, Elio
AU - Plazzi, Giuseppe
PY - 2011/12
Y1 - 2011/12
N2 - Objective: We carried out a systematic video-polysomnographic analysis of the number and type of motor events during REM sleep in narcolepsy-cataplexy patients with REM sleep behavior disorder (NC + RBD) but not clinical RBD (NC - RBD). Methods: Twelve NC + RBD and 10 NC - RBD male patients underwent video-polysomnography (video-PSG). Motor events of different type and complexity (i.e., elementary and complex movements and vocalizations) occurring during REM sleep were visually assessed, and indices of their frequency per hour of REM sleep were calculated. Subsequently, the index values were compared in NC + RBD versus NC - RBD patients. Results: Typical RBD behaviors observed in five NC + RBD patients were not included in any type of motor events. No objective conventional sleep parameter, including visual analysis of chin electromyographic (EMG) activity, significantly differed between the two groups of NC patients. NC + RBD patients showed higher occurrence of elementary movements (p=0.034) during REM sleep compared with NC - RBD patients, but the occurrence of complex movements did not differ significantly. Conclusions: Video-analysis of motor events during REM sleep may improve the diagnosis of RBD in NC. RBD in NC patients is mainly characterized by elementary rather than complex movements, consistent with the view that RBD with NC patients displays a distinct phenotype with respect to other RBD patients.
AB - Objective: We carried out a systematic video-polysomnographic analysis of the number and type of motor events during REM sleep in narcolepsy-cataplexy patients with REM sleep behavior disorder (NC + RBD) but not clinical RBD (NC - RBD). Methods: Twelve NC + RBD and 10 NC - RBD male patients underwent video-polysomnography (video-PSG). Motor events of different type and complexity (i.e., elementary and complex movements and vocalizations) occurring during REM sleep were visually assessed, and indices of their frequency per hour of REM sleep were calculated. Subsequently, the index values were compared in NC + RBD versus NC - RBD patients. Results: Typical RBD behaviors observed in five NC + RBD patients were not included in any type of motor events. No objective conventional sleep parameter, including visual analysis of chin electromyographic (EMG) activity, significantly differed between the two groups of NC patients. NC + RBD patients showed higher occurrence of elementary movements (p=0.034) during REM sleep compared with NC - RBD patients, but the occurrence of complex movements did not differ significantly. Conclusions: Video-analysis of motor events during REM sleep may improve the diagnosis of RBD in NC. RBD in NC patients is mainly characterized by elementary rather than complex movements, consistent with the view that RBD with NC patients displays a distinct phenotype with respect to other RBD patients.
KW - Dream enactment
KW - Narcolepsy-cataplexy
KW - REM sleep
KW - REM sleep behavior disorder
KW - Simple and complex motor events
KW - Video-PSG recording
KW - Vocalizations
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U2 - 10.1016/j.sleep.2011.10.013
DO - 10.1016/j.sleep.2011.10.013
M3 - Article
C2 - 22136902
AN - SCOPUS:82855160984
SN - 1389-9457
VL - 12
JO - Sleep Medicine
JF - Sleep Medicine
IS - SUPPL. 2
ER -