Morphology and molecular features of rare colorectal carcinoma histotypes

Andrea Remo, Matteo Fassan, Alessandro Vanoli, Luca Reggiani Bonetti, Valeria Barresi, Fabiana Tatangelo, Roberta Gafà, Guido Giordano, Massimo Pancione, Federica Grillo, Luca Mastracci

Research output: Contribution to journalReview articlepeer-review


Several histopathological variants of colorectal carcinoma can be distinguished, some associated with specific molecular profiles. However, in routine practice, ninety/ninety-five percent of all large bowel tumors are diagnosed as conventional adenocarcinoma, even though they are a heterogeneous group including rare histotypes, which are often under-recognized. Indeed, colorectal cancer exhibits differences in incidence, location of tumor, pathogenesis, molecular pathways and outcome depending on histotype. The aim is therefore to review the morphological and molecular features of these rare variants of intestinal carcinomas which may hold the key to differences in prognosis and treatment.

Original languageEnglish
Article number1036
Issue number7
Publication statusPublished - Jul 2019


  • Adenocarcinoma with osseous metaplasia
  • Clear cell carcinoma
  • Colorectal cancer histotypes
  • Cribriform/comedo-type carcinoma
  • Hepatoid carcinoma
  • Lymphoepitelioma-like carcinoma
  • Medullary carcinoma
  • Micropapillary carcinoma
  • Rhabdoid carcinoma
  • Signet ring cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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