Monocyte chemotactic protein-1 in the regulation of monocyte recruitment

A. Mantovani, B. Bottazzi, F. Colotta, G. Peri, P. Allavena, Gang Dong Quiang Gang Dong, A. Vecchi, S. Sozzani

Research output: Contribution to journalArticlepeer-review


Macrophages are a major component of the lymphoreticular infiltrate of tumors. Tumor-derived cytokines play an important role in the regulation of the recruitment and function of tumor-associated macrophages (TAM), TAM have pleiotropic function that influence various aspects of the immunobiology of neoplastic tissues including vascularization, stroma formation and dissolution, and growth rate. These cells, strategically located at the interface between tumor and host, have the potential to destroy neoplastic tissues and hence are a target for therapeutic intervention. Recent clinical results in ovarian cancer encourage this line.

Original languageEnglish
Pages (from-to)445-448
Number of pages4
JournalRegional Immunology
Issue number5-6
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Immunology


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