Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity

Jane Willoughby; Vivette Glover; Merton Sandler; Alberto Albanese; Peter Jenner; C. David Marsden

doi:10.1016/0304-3940(88)90794-X

Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity

Jane Willoughby, Vivette Glover, Merton Sandler, Alberto Albanese, Peter Jenner, C. David Marsden

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.

Original language	English
Pages (from-to)	100-106
Number of pages	7
Journal	Neuroscience Letters
Volume	90
Issue number	1-2
DOIs	https://doi.org/10.1016/0304-3940(88)90794-X
Publication status	Published - Jul 19 1988

Keywords

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Histochemistry
Marmoset
Monoamine oxidase
Nigrostriatal pathway
Parkinson's disease
Rat

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(88)90794-X

Cite this

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title = "Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity",

abstract = "This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.",

keywords = "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), Histochemistry, Marmoset, Monoamine oxidase, Nigrostriatal pathway, Parkinson's disease, Rat",

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T1 - Monoamine oxidase activity and distribution in marmoset brain

T2 - implications for MPTP toxicity

AU - Willoughby, Jane

AU - Glover, Vivette

AU - Sandler, Merton

AU - Albanese, Alberto

AU - Jenner, Peter

AU - Marsden, C. David

PY - 1988/7/19

Y1 - 1988/7/19

N2 - This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.

AB - This study describes the histochemical localisation of monoamine oxidase (MAO) in marmoset brain. No MAO A staining was observed but MAO B was found in many areas, with medium intensity of staining in the substantia nigra, and high intensity staining in the striatum and nucleus accumbens, among other regions. The high activity in the nigrostriatal tract, compared with the rat, may partially explain the greater sensitivity of the marmoset to MPTP toxicity. As in the rat, high activity was present in the raphe nuclei. However, unlike the rat, no enrichment of MAO B was observed in blood vessels or ventricular linings.

KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

KW - Histochemistry

KW - Marmoset

KW - Monoamine oxidase

KW - Nigrostriatal pathway

KW - Parkinson's disease

KW - Rat

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Monoamine oxidase activity and distribution in marmoset brain: implications for MPTP toxicity

Abstract

Keywords

ASJC Scopus subject areas

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