Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients

Maria Libera Ascierto, Michael O. Idowu, Yingdong Zhao, Hanif Khalak, Kyle K. Payne, Xiang Yang Wang, Catherine I. Dumur, Davide Bedognetti, Sara Tomei, Paolo A. Ascierto, Anil Shanker, Harry D. Bear, Ena Wang, Francesco M. Marincola, Andrea De Maria, Masoud H. Manjili

Research output: Contribution to journalArticlepeer-review


Background: Recent observations suggest that immune-mediated tissue destruction is dependent upon coordinate activation of immune genes expressed by cells of the innate and adaptive immune systems.Methods: Here, we performed a retrospective pilot study to investigate whether the coordinate expression of molecular signature mostly associated with NK cells could be used to segregate breast cancer patients into relapse and relapse-free outcomes.Results: By analyzing primary breast cancer specimens derived from patients who experienced either 58-116 months (~5-9 years) relapse-free survival or developed tumor relapse within 9-76 months (~1-6 years) we found that the expression of molecules involved in activating signaling of NK cells and in NK cells: target interaction is increased in patients with favorable prognosis.Conclusions: The parameters identified in this study, together with the prognostic signature previously reported by our group, highlight the cooperation between the innate and adaptive immune components within the tumor microenvironment.

Original languageEnglish
Article number145
JournalJournal of Translational Medicine
Issue number1
Publication statusPublished - Jun 12 2013


  • Breast cancer prognosis
  • Innate immunity
  • Molecular markers
  • NK cells
  • Tumour microenvironment
  • Tumour relapse

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)


Dive into the research topics of 'Molecular signatures mostly associated with NK cells are predictive of relapse free survival in breast cancer patients'. Together they form a unique fingerprint.

Cite this