TY - JOUR
T1 - MLL-MLLT10 fusion in acute monoblastic leukemia
T2 - Variant complex rearrangements and 11q proximal breakpoint heterogeneity
AU - Morerio, Cristina
AU - Rapella, Annamaria
AU - Rosanda, Cristina
AU - Lanino, Edoardo
AU - Lo Nigro, Luca
AU - Di Cataldo, Andrea
AU - Maserati, Emanuela
AU - Pasquali, Francesco
AU - Panarello, Claudio
PY - 2004/7/15
Y1 - 2004/7/15
N2 - Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneity.
AB - Cytogenetic studies of acute monoblastic leukemia cases presenting MLL-MLLT10 (alias MLL-AF10) fusion show a broad heterogeneity of chromosomal breakpoints. We present two new pediatric cases (French-American-British type M5) with MLL-MLLT10 fusion, which we studied with fluorescence in situ hybridization. In both we detected a paracentric inversion of the 11q region that translocated onto chromosome 10p12; one case displayed a variant complex pattern. We review the cytogenetic molecular data concerning the proximal inversion breakpoint of 11q and confirm its heterogeneity.
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U2 - 10.1016/j.cancergencyto.2003.11.012
DO - 10.1016/j.cancergencyto.2003.11.012
M3 - Article
C2 - 15262427
AN - SCOPUS:3242691426
SN - 0165-4608
VL - 152
SP - 108
EP - 112
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
IS - 2
ER -