TY - JOUR
T1 - Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS
AU - Hidalgo Carcedo, Cristina
AU - Donazzi, Matteo
AU - Spano, Stefania
AU - Turacchio, Gabriele
AU - Colanzi, Antonino
AU - Luini, Alberto
AU - Corda, Daniela
PY - 2004/7/2
Y1 - 2004/7/2
N2 - Organette inheritance is an essential feature of all eukaryotic cells. As with other organelles, the Golgi complex partitions between daughter cells through the fission of its membranes into numerous tubulovesicular fragments. We found that the protein CtBP3/BARS (BARS) was responsible for driving the fission of Golgi membranes during mitosis in vivo. Moreover, by in vitro analysis, we identified two stages of this Golgi fragmentation process: disassembly of the Golgi stacks into a tubular network, and BARS-dependent fission of these tubules. Finally, this BARS-induced fission of Golgi membranes controlled the G2-to-prophase transition of the cell cycle, and hence cell division.
AB - Organette inheritance is an essential feature of all eukaryotic cells. As with other organelles, the Golgi complex partitions between daughter cells through the fission of its membranes into numerous tubulovesicular fragments. We found that the protein CtBP3/BARS (BARS) was responsible for driving the fission of Golgi membranes during mitosis in vivo. Moreover, by in vitro analysis, we identified two stages of this Golgi fragmentation process: disassembly of the Golgi stacks into a tubular network, and BARS-dependent fission of these tubules. Finally, this BARS-induced fission of Golgi membranes controlled the G2-to-prophase transition of the cell cycle, and hence cell division.
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U2 - 10.1126/science.1097775
DO - 10.1126/science.1097775
M3 - Article
C2 - 15232108
AN - SCOPUS:3042795657
SN - 0036-8075
VL - 305
SP - 93
EP - 96
JO - Science
JF - Science
IS - 5680
ER -