Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS

Cristina Hidalgo Carcedo, Matteo Donazzi, Stefania Spano, Gabriele Turacchio, Antonino Colanzi, Alberto Luini, Daniela Corda

Research output: Contribution to journalArticlepeer-review


Organette inheritance is an essential feature of all eukaryotic cells. As with other organelles, the Golgi complex partitions between daughter cells through the fission of its membranes into numerous tubulovesicular fragments. We found that the protein CtBP3/BARS (BARS) was responsible for driving the fission of Golgi membranes during mitosis in vivo. Moreover, by in vitro analysis, we identified two stages of this Golgi fragmentation process: disassembly of the Golgi stacks into a tubular network, and BARS-dependent fission of these tubules. Finally, this BARS-induced fission of Golgi membranes controlled the G2-to-prophase transition of the cell cycle, and hence cell division.

Original languageEnglish
Pages (from-to)93-96
Number of pages4
Issue number5680
Publication statusPublished - Jul 2 2004

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Mitotic Golgi partitioning is driven by the membrane-fissioning protein CtBP3/BARS'. Together they form a unique fingerprint.

Cite this