TY - JOUR
T1 - Mind the gap
T2 - The mismatch between clinical and imaging metrics in ALS
AU - Verstraete, Esther
AU - Turner, Martin R.
AU - Grosskreutz, Julian
AU - Filippi, Massimo
AU - Benatar, Michael
PY - 2015/11/27
Y1 - 2015/11/27
N2 - Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and as such deliver biomarkers relevant to diagnosis, prognosis and monitoring disease progression. However, a correlation between imaging parameters and clinical metrics has thus far been inconsistent across studies. We discuss the contributing factors to this clinical-imaging correlation gap as well as its implications for future research.
AB - Advanced magnetic resonance imaging (MRI) techniques hold the promise to capture upper motor neuron loss and extramotor brain changes in amyotrophic lateral sclerosis (ALS) and as such deliver biomarkers relevant to diagnosis, prognosis and monitoring disease progression. However, a correlation between imaging parameters and clinical metrics has thus far been inconsistent across studies. We discuss the contributing factors to this clinical-imaging correlation gap as well as its implications for future research.
UR - http://www.scopus.com/inward/record.url?scp=84947494774&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947494774&partnerID=8YFLogxK
U2 - 10.3109/21678421.2015.1051989
DO - 10.3109/21678421.2015.1051989
M3 - Article
AN - SCOPUS:84947494774
SN - 2167-8421
VL - 16
SP - 524
EP - 529
JO - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
JF - Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
IS - 7-8
ER -