Migratory conventional dendritic cells in the induction of peripheral T cell tolerance

Achille Broggi, Ivan Zanoni, Francesca Granucci

Research output: Contribution to journalArticlepeer-review


Conventional DCs are an extremely heterogeneous cell population that comprises several different subsets. A major distinction can be made between lymphoid-resident DCs that are present in the lymphoid tissues and the blood and migratory DCs that reside in the nonlymphoid tissues and migrate to the lymph nodes, both in homeostatic conditions and during the course of an infection. Migratory DCs differ from tissue to tissue but share the unique ability to transport antigens to the draining lymph nodes-in particular, tissue-restricted antigens in homeostatic conditions and microbial antigens after an infection. Recently, steady-state migratory DCs have gained much attention after the discovery of their high tolerogenic potential. The purpose of this review is to give a picture of the recent finding regarding steady-state migratory DCs with particular interest in their role in inducing T cell tolerance.

Original languageEnglish
Pages (from-to)903-911
Number of pages9
JournalJournal of Leukocyte Biology
Issue number5
Publication statusPublished - Nov 2013


  • Lamina propria
  • Mesenteric lymph nodes
  • Retinoic acid
  • Skindraining lymph nodes

ASJC Scopus subject areas

  • Cell Biology
  • Immunology


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