Microvascular brain damage with aging and hypertension: Pathophysiological consideration and clinical implications

Angelo Scuteri, Peter M. Nilsson, Christopher Tzourio, Josep Redon, Stephane Laurent

Research output: Contribution to journalArticlepeer-review


Loss of cognitive function and hypertension are two common conditions in the elderly and both significantly contribute to loss of personal independency. Microvascular brain damage-the result of age-associated alteration in large arteries and the progressive mismatch of their cross-talk with small cerebral arteries-represents a potent risk factor for cognitive decline and for the onset of dementia in older individuals. The present review discusses the complexity of factors linking large artery to microvascular brain disease and to cognitive decline and the evidence for possible clinical markers useful for prevention of this phenomenon. The possibility of dementia prevention by cardiovascular risk factors control has not been demonstrated. In the absence of research clinical trials specifically and primarily designed to demonstrate the antihypertensive treatment efficacy for reducing the risk of dementia, further evidence demonstrating that it is possible to limit the progression of microvascular brain damage is needed.

Original languageEnglish
Pages (from-to)1469-1477
Number of pages9
JournalJournal of Hypertension
Issue number8
Publication statusPublished - Aug 2011


  • arterial aging
  • arterial stiffness
  • cognitive function
  • dementia
  • microvascular brain damage
  • prevention
  • white matter lesion

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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