MicroRNAs in the pathogeny of chronic lymphocytic leukaemia

Milena S. Nicoloso; Thomas J. Kipps; Carlo M. Croce; George A. Calin

doi:10.1111/j.1365-2141.2007.06868.x

MicroRNAs in the pathogeny of chronic lymphocytic leukaemia

Milena S. Nicoloso, Thomas J. Kipps, Carlo M. Croce, George A. Calin

Centro di Riferimento Oncologico

Research output: Contribution to journal › Article › peer-review

Abstract

MicroRNAs (miRNAs) have been linked to the initiation and progression of chronic lymphocytic leukaemia (CLL). The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein-coding genes. Recent studies have shown that miRNAs are the main candidates for the elusive class of CLL predisposing genes. These discoveries could be exploited for the development of useful markers for diagnosis and prognosis, as well as for the development of new RNA-based cancer therapies.

Original language	English
Pages (from-to)	709-716
Number of pages	8
Journal	British Journal of Haematology
Volume	139
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-2141.2007.06868.x
Publication status	Published - Dec 2007

Keywords

BCL2
Chronic lymphocytic leukaemia
MicroRNAs
Mutations

ASJC Scopus subject areas

Hematology

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10.1111/j.1365-2141.2007.06868.x

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abstract = "MicroRNAs (miRNAs) have been linked to the initiation and progression of chronic lymphocytic leukaemia (CLL). The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein-coding genes. Recent studies have shown that miRNAs are the main candidates for the elusive class of CLL predisposing genes. These discoveries could be exploited for the development of useful markers for diagnosis and prognosis, as well as for the development of new RNA-based cancer therapies.",

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AU - Croce, Carlo M.

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AB - MicroRNAs (miRNAs) have been linked to the initiation and progression of chronic lymphocytic leukaemia (CLL). The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein-coding genes. Recent studies have shown that miRNAs are the main candidates for the elusive class of CLL predisposing genes. These discoveries could be exploited for the development of useful markers for diagnosis and prognosis, as well as for the development of new RNA-based cancer therapies.

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KW - MicroRNAs

KW - Mutations

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MicroRNAs in the pathogeny of chronic lymphocytic leukaemia

Abstract

Keywords

ASJC Scopus subject areas

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