TY - JOUR
T1 - MicroRNAs in cancer
T2 - Small molecules with a huge impact
AU - Iorio, Marilena V.
AU - Croce, Carlo M.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Every cellular process is likely to be regulated by microRNAs, and an aberrant microRNA expression signature is a hallmark of several diseases, including cancer. MicroRNA expression profiling has indeed provided evidence of the association of these tiny molecules with tumor development and progression. An increasing number of studies have then demonstrated that microRNAs can function as potential oncogenes or oncosuppressor genes, depending on the cellular context and on the target genes they regulate. Here we review our current knowledge about the involvement of microRNAs in cancer and their potential as diagnostic, prognostic, and therapeutic tools.
AB - Every cellular process is likely to be regulated by microRNAs, and an aberrant microRNA expression signature is a hallmark of several diseases, including cancer. MicroRNA expression profiling has indeed provided evidence of the association of these tiny molecules with tumor development and progression. An increasing number of studies have then demonstrated that microRNAs can function as potential oncogenes or oncosuppressor genes, depending on the cellular context and on the target genes they regulate. Here we review our current knowledge about the involvement of microRNAs in cancer and their potential as diagnostic, prognostic, and therapeutic tools.
UR - http://www.scopus.com/inward/record.url?scp=73349125465&partnerID=8YFLogxK
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U2 - 10.1200/JCO.2009.24.0317
DO - 10.1200/JCO.2009.24.0317
M3 - Article
C2 - 19884536
AN - SCOPUS:73349125465
SN - 0732-183X
VL - 27
SP - 5848
EP - 5856
JO - Journal of Clinical Oncology
JF - Journal of Clinical Oncology
IS - 34
ER -