MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity

F Capitano, J Camon, V. Licursi, V Ferretti, L Maggi, Maria Scianni, G. Del Vecchio, A Rinaldi, C. Mannironi, C Limatola, C. Presutti, A. Mele

Research output: Contribution to journalArticlepeer-review


MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plasticity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalNeurobiology of Learning and Memory
Early online dateDec 27 2016
Publication statusPublished - Mar 2017


  • Journal Article


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