MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity

F Capitano; J Camon; V. Licursi; V Ferretti; L Maggi; Maria Scianni; G. Del Vecchio; A Rinaldi; C. Mannironi; C Limatola; C. Presutti; A. Mele

doi:10.1016/j.nlm.2016.12.019

MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity

F Capitano, J Camon, V. Licursi, V Ferretti, L Maggi, Maria Scianni, G. Del Vecchio, A Rinaldi, C. Mannironi, C Limatola, C. Presutti, A. Mele

Research output: Contribution to journal › Article › peer-review

Abstract

MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plasticity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.

Original language	English
Pages (from-to)	63-68
Number of pages	6
Journal	Neurobiology of Learning and Memory
Volume	139
Early online date	Dec 27 2016
DOIs	https://doi.org/10.1016/j.nlm.2016.12.019
Publication status	Published - Mar 2017

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10.1016/j.nlm.2016.12.019

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title = "MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity",

abstract = "MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plasticity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.",

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author = "F Capitano and J Camon and V. Licursi and V Ferretti and L Maggi and Maria Scianni and {Del Vecchio}, G. and A Rinaldi and C. Mannironi and C Limatola and C. Presutti and A. Mele",

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AU - Capitano, F

AU - Camon, J

AU - Licursi, V.

AU - Ferretti, V

AU - Maggi, L

AU - Scianni, Maria

AU - Del Vecchio, G.

AU - Rinaldi, A

AU - Mannironi, C.

AU - Limatola, C

AU - Presutti, C.

AU - Mele, A.

PY - 2017/3

Y1 - 2017/3

N2 - MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plasticity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.

AB - MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plasticity. To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the intracellular pathways that mediate experience-dependent changes in the brain.

KW - Journal Article

U2 - 10.1016/j.nlm.2016.12.019

DO - 10.1016/j.nlm.2016.12.019

M3 - Article

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SN - 1074-7427

VL - 139

SP - 63

EP - 68

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

ER -

MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity

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