Microalbuminuria in never-treated hypertensives: Lack of relationship to hyperinsulinemia and genetic predisposition to hypertension

Anna M. Grandi, Rosa Santillo, Paolo Zanzi, Roberta Broggi, Daniela Imperiale, Sara Colombo, Andrea Bertolini, Alessandro Jessula, Elisabetta Selva, Luigina Guasti, Achille Venco

Research output: Contribution to journalArticlepeer-review


We evaluated the relationship of microalbuminuria to hyperinsulinemia and family history of hypertension in 92 never-treated essential hypertensives (mean 24-h blood pressure > 140 or 90 mm Hg), with positive (F+) or negative (F-) family history of hypertension: 31 had microalbuminuria (MA+) (urinary albumin excretion [UAE], 30 to 300 mg/24 h) and 61 had normal (4/ insulin x glucose values at glucose peak). Subjects with and without microalbuminuria did not differ with regard to age, sex, body mass index, and 24-h heart rate, whereas 24-h, daytime, and nighttime systolic and diastolic blood pressure were significantly higher in MA+ than MA- patients. The prevalence of positive family history of hypertension was similar between MA+ and MA-, as were fasting and stimulated glucose and insulin values and the index of peripheral insulin activity. Subdividing the patients on the basis of family history of hypertension (59 F+, 33 F-) UAE was not significantly different between F+ and F-. UAE did not correlate with glucose and insulin parameters. From our results, in never-treated hypertensives, microalbuminuria is associated with higher blood pressure values, but is related neither to genetic predisposition to hypertension, nor to hyperinsulinemia; therefore, impaired insulin sensitivity and microalbuminuria are two components of the hypertensive syndrome, largely independent of each other. (C) 2000 American Journal of Hypertension, Ltd.

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalAmerican Journal of Hypertension
Issue number4 I
Publication statusPublished - 2000


  • Family history of hypertension
  • Hyperinsulinemia
  • Hypertension
  • Microalbuminuria

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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