Abstract
We have evaluated the efficacy and toxicity of a chemotherapy consisting of methotrexate, mitoxantrone, 5-Fluorouracil and leucovorin in 21 advanced breast cancer patients. Among 20 evaluable patients, objective response was obtained in 6 patients (30%) with two complete responses, stable disease in 4 patients (20%), while 10 patients (50%) progressed. Median progression-free survival and survival were 10 and 15 months, respectively. The most frequently observed side-effects were myelosuppression and emesis; one patient, who had previously received doxorubicin at the maximum dose-limiting cardiac toxicity, died of congestive heart failure after the third cycle. This treatment is moderately effective for advanced breast cancer patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1423-1425 |
| Number of pages | 3 |
| Journal | Anticancer Research |
| Volume | 14 |
| Issue number | 3 B |
| Publication status | Published - 1994 |
Keywords
- Biochemical modulation
- Breast cancer
- Salvage treatment
ASJC Scopus subject areas
- Cancer Research
- Oncology