Methicillin-resistant Staphylococcus aureus: A community health threat

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Methicillin-resistant Staphylococcus aureus (MRSA), one of the most common causes of infections, has been traditionally recognized as a nosocomial pathogen. However, in recent years, its epidemiology has radically changed, being now observed even more frequently in the community, and accounting for > 50% of staphylococcal infections in the US outpatient setting. Community-acquired (CA)-MRSA strains typically cause infections among otherwise healthy individuals, with risk factors differing from those of nosocomial MRSA. The clinical manifestations may range from a furuncle to life-threatening infections, such as necrotizing fasciitis and pneumonia. The antibiotic treatment of these infections may also differ because CA-MRSA strains often retain susceptibility to antimicrobials other than glycopeptides and newer agents. Moreover, the production of toxins, such as the Panton-Valentine leukocidin (PVL), should influence the antibiotic choice because in these cases the use of a combination therapy with antimicrobial agents able to decrease toxin production is suggested. There are still many unanswered key questions regarding the epidemiology, prevention, and treatment of CA-MRSA infections. This article REs current knowledge of CA-MRSA.

Original languageEnglish
Pages (from-to)16-23
Number of pages8
JournalPostgraduate Medicine
Issue number6
Publication statusPublished - Nov 2010


  • Antimicrobials
  • Drug resistance
  • Methicillin-resistant Staphylococcus aureus

ASJC Scopus subject areas

  • Medicine(all)


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