Methicillin Resistance in Staphylococcus aureus

Edoardo Carretto, Rosa Visiello, Paola Nardini

Research output: Chapter in Book/Report/Conference proceedingChapter


Methicillin-resistant Staphylococcus aureus (MRSA) was identified in clinical isolates only a few years after the introduction of this drug in clinical practice. This resistance trait has become common and spread worldwide due to the diffusion of epidemic clones, and MRSA has become one of the most frequently isolated nosocomial pathogens. Recently, methicillin-resistant isolates either from livestock or that were community-acquired have gained importance in clinical microbiology. The incidence of MRSA currently varies from country to country and, in the same country, from hospital to hospital. In this chapter, the mechanism of methicillin resistance is described, with particular emphasis on the structure of the SCC. mec cassette and details regarding differentiation of these isolates from a molecular point of view.

Original languageEnglish
Title of host publicationPet-to-Man Travelling Staphylococci
Subtitle of host publicationA World in Progress
PublisherElsevier Inc.
Number of pages11
ISBN (Electronic)9780128135488
ISBN (Print)9780128135471
Publication statusPublished - Mar 16 2018
Externally publishedYes


  • MecA gene
  • MecC gene
  • Methicillin resistance
  • Molecular detection of resistance traits
  • SCCmec cassette

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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