TY - GEN
T1 - Methamphetamine fails to alter the noradrenergic integrity of the heart
T2 - A comparison with the parkinsonism-inducing neurotoxin MPTP
AU - Ruffoli, Riccardo
AU - Soldani, Paola
AU - Pasquali, Livia
AU - Ruggieri, Stefano
AU - Paparelli, Antonio
AU - Fornai, Francesco
PY - 2008/10
Y1 - 2008/10
N2 - The chronic use of methamphetamine leads to cardiomyopathy and a nigrostriatal dopamine deficiency that partly mimics what occurs in Parkinson's disease. This study examines the cardiac effects occurring after chronic administration of methamphetamine and parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Despite the similarities concerning the nigrostriatal dopamine denervation, methamphetamine failed to produce chronic norepinephrine depletion in the heart, thus contrasting with what occurs in Parkinson's disease or after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These data suggest that the chronic cardiovascular effects induced by methamphetamine rely on biochemical changes which differ from those activated by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine or during the course of Parkinson's disease.
AB - The chronic use of methamphetamine leads to cardiomyopathy and a nigrostriatal dopamine deficiency that partly mimics what occurs in Parkinson's disease. This study examines the cardiac effects occurring after chronic administration of methamphetamine and parkinsonism-inducing neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Despite the similarities concerning the nigrostriatal dopamine denervation, methamphetamine failed to produce chronic norepinephrine depletion in the heart, thus contrasting with what occurs in Parkinson's disease or after administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. These data suggest that the chronic cardiovascular effects induced by methamphetamine rely on biochemical changes which differ from those activated by 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine or during the course of Parkinson's disease.
KW - Cardiac noradrenergic innervation
KW - Methamphetamine
KW - MPTP
KW - Parkinson's disease
KW - Parkinsonian heart
UR - http://www.scopus.com/inward/record.url?scp=53549087549&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53549087549&partnerID=8YFLogxK
U2 - 10.1196/annals.1432.017
DO - 10.1196/annals.1432.017
M3 - Conference contribution
C2 - 18991879
AN - SCOPUS:53549087549
SN - 9781573317184
VL - 1139
T3 - Annals of the New York Academy of Sciences
SP - 337
EP - 344
BT - Annals of the New York Academy of Sciences
ER -