Metastatic potential of metastases, tumor cell heterogeneity, and therapeutic implications.

F. Spreafico, A. Mantovani, R. Giavazzi, G. Conti, A. Anaclerio

Research output: Contribution to journalArticlepeer-review


The metastasizing capacity of spontaneous metastases of several murine tumors of different histology, origin, and disseminative pattern was investigated to test the hypothesis that metastases originate from various subpopulations within the primary tumor. Overall, tumor cells from individual metastases did not show greater metastasizing capacity than the cells of the original tumor, although a degree of heterogeneity was seen. Differences in the immunologic profile among metastases of the same tumor were also observed. The possible therapeutic implications of these findings are discussed.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Publication statusPublished - 1982

ASJC Scopus subject areas

  • Medicine(all)


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