Metabolite changes in normal appearing cervical spinal cord in two patients with multiple sclerosis. A proton MR spectroscopic analysis

M. Maffei; A. F. Marliani; F. Salvi; V. Clementi; R. Agati; M. Leonardi

Metabolite changes in normal appearing cervical spinal cord in two patients with multiple sclerosis. A proton MR spectroscopic analysis

M. Maffei, A. F. Marliani, F. Salvi, V. Clementi, R. Agati, M. Leonardi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article › peer-review

Abstract

We describe two cases of multiple sclerosis (MS) analyzed with Proton MR Spectroscopy (¹H-MRS) with the voxel placed along the main axis of the normal appearing cervical spinal cord over three main space planes, orthogonally set. Relative concentrations expressed by the absolute concentration ratios of total NAA (tNAA), choline (Cho), myo-inositol (mI) and creatine plus phosphocreatine (Cr) were compared with the metabolites of ten healthy volunteers. We found a significant increase in mI/Cr and a small increase in Cho/Cr in the first patient, whereas the second patient had a decrease in NAA/Cr and NAA/Cho ratios. 1H-MRS will disclose biochemical changes in MS, even in normal appearing spinal cord, as already described in normal appearing cerebral tissue: these biochemical changes may provide significant information on disease prognosis.

Original language	English
Pages (from-to)	228-235
Number of pages	8
Journal	Neuroradiology Journal
Volume	21
Issue number	2
Publication status	Published - Apr 2008

Keywords

3 Tesla
Metabolite quantification
Multiple sclerosis
Proton magnetic resonance spectroscopy
Spinal cord

ASJC Scopus subject areas

Clinical Neurology
Radiology Nuclear Medicine and imaging

Cite this

@article{0930d5de6db94be286aef6cd3bc0a835,

title = "Metabolite changes in normal appearing cervical spinal cord in two patients with multiple sclerosis. A proton MR spectroscopic analysis",

abstract = "We describe two cases of multiple sclerosis (MS) analyzed with Proton MR Spectroscopy (1H-MRS) with the voxel placed along the main axis of the normal appearing cervical spinal cord over three main space planes, orthogonally set. Relative concentrations expressed by the absolute concentration ratios of total NAA (tNAA), choline (Cho), myo-inositol (mI) and creatine plus phosphocreatine (Cr) were compared with the metabolites of ten healthy volunteers. We found a significant increase in mI/Cr and a small increase in Cho/Cr in the first patient, whereas the second patient had a decrease in NAA/Cr and NAA/Cho ratios. 1H-MRS will disclose biochemical changes in MS, even in normal appearing spinal cord, as already described in normal appearing cerebral tissue: these biochemical changes may provide significant information on disease prognosis.",

keywords = "3 Tesla, Metabolite quantification, Multiple sclerosis, Proton magnetic resonance spectroscopy, Spinal cord",

author = "M. Maffei and Marliani, {A. F.} and F. Salvi and V. Clementi and R. Agati and M. Leonardi",

year = "2008",

month = apr,

language = "English",

volume = "21",

pages = "228--235",

journal = "Neuroradiology Journal",

issn = "1971-4009",

publisher = "Centauro srl",

number = "2",

}

TY - JOUR

T1 - Metabolite changes in normal appearing cervical spinal cord in two patients with multiple sclerosis. A proton MR spectroscopic analysis

AU - Maffei, M.

AU - Marliani, A. F.

AU - Salvi, F.

AU - Clementi, V.

AU - Agati, R.

AU - Leonardi, M.

PY - 2008/4

Y1 - 2008/4

N2 - We describe two cases of multiple sclerosis (MS) analyzed with Proton MR Spectroscopy (1H-MRS) with the voxel placed along the main axis of the normal appearing cervical spinal cord over three main space planes, orthogonally set. Relative concentrations expressed by the absolute concentration ratios of total NAA (tNAA), choline (Cho), myo-inositol (mI) and creatine plus phosphocreatine (Cr) were compared with the metabolites of ten healthy volunteers. We found a significant increase in mI/Cr and a small increase in Cho/Cr in the first patient, whereas the second patient had a decrease in NAA/Cr and NAA/Cho ratios. 1H-MRS will disclose biochemical changes in MS, even in normal appearing spinal cord, as already described in normal appearing cerebral tissue: these biochemical changes may provide significant information on disease prognosis.

AB - We describe two cases of multiple sclerosis (MS) analyzed with Proton MR Spectroscopy (1H-MRS) with the voxel placed along the main axis of the normal appearing cervical spinal cord over three main space planes, orthogonally set. Relative concentrations expressed by the absolute concentration ratios of total NAA (tNAA), choline (Cho), myo-inositol (mI) and creatine plus phosphocreatine (Cr) were compared with the metabolites of ten healthy volunteers. We found a significant increase in mI/Cr and a small increase in Cho/Cr in the first patient, whereas the second patient had a decrease in NAA/Cr and NAA/Cho ratios. 1H-MRS will disclose biochemical changes in MS, even in normal appearing spinal cord, as already described in normal appearing cerebral tissue: these biochemical changes may provide significant information on disease prognosis.

KW - 3 Tesla

KW - Metabolite quantification

KW - Multiple sclerosis

KW - Proton magnetic resonance spectroscopy

KW - Spinal cord

UR - http://www.scopus.com/inward/record.url?scp=42449146203&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42449146203&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:42449146203

SN - 1971-4009

VL - 21

SP - 228

EP - 235

JO - Neuroradiology Journal

JF - Neuroradiology Journal

IS - 2

ER -

Metabolite changes in normal appearing cervical spinal cord in two patients with multiple sclerosis. A proton MR spectroscopic analysis

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this