Metabolism in the Tumor Microenvironment

Francesca Montenegro, Stefano Indraccolo

Research output: Chapter in Book/Report/Conference proceedingChapter


From a general perspective, in the context of solid tumors, we can distinguish metabolic alterations of cancer cells from those of the stroma. These two components interact with each other and with the extracellular matrix (ECM), and these interactions can take the form of either metabolic competition or metabolic symbiosis. The aim of this chapter is to overview the canonical metabolic alterations of tumor and stroma cells and to present specific examples of metabolic competition and symbiosis. We will also discuss the complexity and plasticity of metabolism, which pose indeed a serious threat to our ability to target selective metabolic features of tumor microenvironment with drugs. Finally, we will highlight some limitations of state-of-the-art techniques used to study tumor metabolism and propose some innovative solutions to investigate the clinical relevance of metabolic alterations for patient management and treatment.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Number of pages11
Publication statusPublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Angiogenesis
  • Glucose
  • Glutamine
  • Glycolysis
  • Hypoxia
  • Immune cell
  • Lactate
  • Lipids
  • Metabolic competition
  • Metabolic symbiosis
  • Metabolism
  • Microenvironment
  • Stroma
  • Tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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